Methanethiol metabolism in the rat

Journal Article · Tue Mar 01 00:00:00 EST 1983 · Res. Commun. Chem. Pathol. Pharmacol.; (United States)

OSTI ID:7007891

Derr, R F; Draves, K

Methanethiol is associated with hepatic failure in humans and the synergistic action of methanethiol, ammonia and octanoate is sufficient to account for the coma of experimental hepatic necrosis. The sulfur atom of methanethiol is eliminated from the body as urinary sulfate at a rate which is approximated by a hyperbola such that 94% is excreted within 21 h after administration. Rats in octanoate or hepatic coma excreted only little sulfate in their urine.

• Research Organization: Veterans Administration Medical Center, Minneapolis, MN
• OSTI ID: 7007891
• Journal Information: Res. Commun. Chem. Pathol. Pharmacol.; (United States), Vol. 39:3
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
SULFATES
EXCRETION
SULFUR ISOTOPES
METABOLISM
THIOLS
LIVER
NECROSIS
OCTANOIC ACID
RATS
RETENTION FUNCTIONS
URINARY TRACT
URINE
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CLEARANCE
DIGESTIVE SYSTEM
FUNCTIONS
GLANDS
ISOTOPES
MAMMALS
MATERIALS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
RODENTS
SULFUR COMPOUNDS
VERTEBRATES
WASTES
550501* - Metabolism- Tracer Techniques
560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)