Extensive amino acid sequence homologies between animal lectins

Journal Article · Tue Sep 01 00:00:00 EDT 1987 · Proc. Natl. Acad. Sci. U.S.A.; (United States)

DOI:https://doi.org/10.1073/pnas.84.18.6345· OSTI ID:7000976

Paroutaud, P; Levi, G; Teichberg, V I; Strosberg, A D

The authors have established the amino acid sequence of the ..beta..-D-galactoside binding lectin from the electric eel and the sequences of several peptides from a similar lectin isolated from human placenta. These sequences were compared with the published sequences of peptides derived from the ..beta..-D-galactoside binding lectin from human lung and with sequences deduced from cDNAs assigned to the ..beta..-D-galactoside binding lectins from chicken embryo skin and human hepatomas. Significant homologies were observed. One of the highly conserved regions that contains a tryptophan residue and two glutamic acid resides is probably part of the ..beta..-D-galactoside binding site, which, on the basis of spectroscopic studies of the electric eel lectin, is expected to contain such residues. The similarity of the hydropathy profiles and the predicted secondary structure of the lectins from chicken skin and electric eel, in spite of differences in their amino acid sequences, strongly suggests that these proteins have maintained structural homologies during evolution and together with the other ..beta..-D-galactoside binding lectins were derived form a common ancestor gene.

• Research Organization: University Paris, VIII (France)
• OSTI ID: 7000976
• Journal Information: Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 84:18
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
LECTINS
AMINO ACID SEQUENCE
BIOLOGICAL EVOLUTION
CHICKENS
EEL
ELECTROPHORESIS
EMBRYOS
GLUTAMIC ACID
HEPATOMAS
LIQUID COLUMN CHROMATOGRAPHY
MAN
PLACENTA
RECOMBINANT DNA
SKIN
TRYPTOPHAN
AMINO ACIDS
ANIMALS
AQUATIC ORGANISMS
AROMATICS
AZAARENES
AZOLES
BIRDS
BODY
CARBOXYLIC ACIDS
CHROMATOGRAPHY
DISEASES
DNA
FETAL MEMBRANES
FISHES
FOWL
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INDOLES
MAMMALS
MEMBRANES
MOLECULAR STRUCTURE
NEOPLASMS
NUCLEIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PRIMATES
PYRROLES
SEPARATION PROCESSES
VERTEBRATES
500200* - Environment
Atmospheric- Chemicals Monitoring & Transport- (-1989)