Space and time sequence and mosaicism of neurogenesis in hippocampal area CA1 in mice
The study of the times and sequence of neuron formation in various structures of the mammalian brain has made substantial progress thanks to the use of autoradiographic techniques, by which the germinative precursors of neurons can be tagged with tritium-thymidine and the subsequent fate of the labeled cells can be followed. The authors study the space and time sequence of neuron formation and look for the presence of mosaicism of neurogenesis in area CA1 of Ammon's horn of the mouse hippocampus, one of the most regularly arranged hippocampal areas. An analysis of the distribution of intensively labeled neurons in areas CA1 showed the presence of groups of intensively labeled neurons alternating with unlabeled and weakly labeled cells.. Mice receiving tritium-thymidine on the 13th-16th day of embryogenesis were most marked when the isotope was injected on the 14th-15th day of embroygeneisis. The investigation showed that a mosaic pattern of neurogenesis exists in the hippocampus, just as in the neocortex, and it can be regarded as the result of asynchronous production of neurons by local areas of the germinative zone, each of which constructs a radial segment of cortex.
- Research Organization:
- Patrice Lumumba Peoples' Friendship University, Moscow
- OSTI ID:
- 6999839
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 100:9
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
EMBRYONIC CELLS
MITOSIS
MICE
HIPPOCAMPUS
NERVE CELLS
AUTORADIOGRAPHY
CELL PROLIFERATION
GERMINATION
INTRAPERITONEAL INJECTION
LABELLING
MIGRATION
ONTOGENESIS
THYMIDINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMAL CELLS
ANIMALS
AZINES
BODY
BRAIN
CELL DIVISION
CENTRAL NERVOUS SYSTEM
HETEROCYCLIC COMPOUNDS
INJECTION
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
RIBOSIDES
RODENTS
SOMATIC CELLS
VERTEBRATES
550301* - Cytology- Tracer Techniques