Control of the level of unusual estrogen-binding protein in rat liver by sex steroids and the pituitary
This paper studies the role of sex steriods and the pituitary in regulation of the unusual estrogen-binding protein (UEBP) level in male rat liver. The concentration of E/sub 2/-binding sites of UEBP in the liver cytosol was determined by measuring binding of a minimal addition of 2,4,6,7-tritium-E/sub 2/, with specific radioactivity of 98-100 Ci/mmole. Data on the effect of hypophysectomy on the UEBP level in the liver of different groups of rats are presented. The presence of comparable quantities of E/sub 2/ and androgens in rats of both sexes is evidence of the existence of a fine mechanism of combined regulation of the UEBP concentration under natural conditions that reflect changes in the absolute E/sub 2/ or androgen levels or in the ratio between them.
- Research Organization:
- M.V. Lomonosov Moscow University
- OSTI ID:
- 6999698
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 100:9
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ESTROGENS
RADIORECEPTOR ASSAY
RECEPTORS
HYPOPHYSECTOMY
BIOLOGICAL EFFECTS
PITUITARY GLAND
BIOLOGICAL FUNCTIONS
PROTEINS
METABOLISM
RATS
LIVER
FEMALES
INTRAMUSCULAR INJECTION
PITUITARY HORMONES
RETENTION
TESTOSTERONE
TRITIUM COMPOUNDS
ANDROGENS
ANDROSTANES
ANIMALS
BODY
DIGESTIVE SYSTEM
ENDOCRINE GLANDS
FUNCTIONS
GLANDS
HORMONES
HYDROXY COMPOUNDS
INJECTION
INTAKE
ISOTOPE APPLICATIONS
KETONES
LABELLED COMPOUNDS
MAMMALS
MEDICINE
MEMBRANE PROTEINS
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
RODENTS
STEROID HORMONES
STEROIDS
SURGERY
TRACER TECHNIQUES
VERTEBRATES
550501* - Metabolism- Tracer Techniques
550201 - Biochemistry- Tracer Techniques