Independent benzodiazepine and beta-carboline binding sites in the brain of aggressive and timid-defensive mice
Journal Article
·
· Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
The authors study the distribution of specific binding sites of labeled benzodiazepine and beta-carboline derivatives in parts of the brain of intact aggressive and timid-defensive mice, and also of animals subjected to subchronic administration of diazepam. The concentrations of /sup 3/H-flunitrazepam and /sup 3/H-beta-carboline-3-carboxylate ethyl ester in the incubation mixture for binding are given. Analysis of their specific binding with brain membranes of animals not receiving diazepam showed that the concentration of specific binding sites for both ligands in both types of mice was significantly higher in the cortex than in other brain regions.
- Research Organization:
- Institute of Pharmacology, Moscow (USSR)
- OSTI ID:
- 6998123
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 103:6; Other Information: Translated from Byull. Ehksp. Biol. Med.; 103: No. 6, 678-681(Jun 1987)
- Country of Publication:
- United States
- Language:
- English
Similar Records
Functional modulation of cerebral gamma-aminobutyric acidA receptor/benzodiazepine receptor/chloride ion channel complex with ethyl beta-carboline-3-carboxylate: Presence of independent binding site for ethyl beta-carboline-3-carboxylate
Protracted treatment with diazepam increases the turnover of putative endogenous ligands for the benzodiazepine/. beta. -carboline recognition site
Study of an octadecaneuropeptide derived from diazepam binding inhibitor (DBI): biological activity and presence in rat brain
Journal Article
·
Tue May 01 00:00:00 EDT 1990
· Journal of Pharmacology and Experimental Therapeutics; (USA)
·
OSTI ID:6998123
Protracted treatment with diazepam increases the turnover of putative endogenous ligands for the benzodiazepine/. beta. -carboline recognition site
Journal Article
·
Sun Mar 01 00:00:00 EST 1987
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:6998123
+2 more
Study of an octadecaneuropeptide derived from diazepam binding inhibitor (DBI): biological activity and presence in rat brain
Journal Article
·
Sat Feb 01 00:00:00 EST 1986
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:6998123
+2 more
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
BRAIN
RADIORECEPTOR ASSAY
DRUGS
BIOLOGICAL EFFECTS
RECEPTORS
MICE
BEHAVIOR
BIOCHEMISTRY
CELL CULTURES
COMPARATIVE EVALUATIONS
INTRAPERITONEAL INJECTION
LABELLING
NERVE CELLS
PSYCHOLOGY
SCINTILLATION COUNTING
TRITIUM COMPOUNDS
ANIMAL CELLS
ANIMALS
BODY
CENTRAL NERVOUS SYSTEM
CHEMISTRY
COUNTING TECHNIQUES
INJECTION
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RODENTS
SOMATIC CELLS
TRACER TECHNIQUES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques
550101 - Behavioral Biology- Tracer Techniques
BRAIN
RADIORECEPTOR ASSAY
DRUGS
BIOLOGICAL EFFECTS
RECEPTORS
MICE
BEHAVIOR
BIOCHEMISTRY
CELL CULTURES
COMPARATIVE EVALUATIONS
INTRAPERITONEAL INJECTION
LABELLING
NERVE CELLS
PSYCHOLOGY
SCINTILLATION COUNTING
TRITIUM COMPOUNDS
ANIMAL CELLS
ANIMALS
BODY
CENTRAL NERVOUS SYSTEM
CHEMISTRY
COUNTING TECHNIQUES
INJECTION
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RODENTS
SOMATIC CELLS
TRACER TECHNIQUES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques
550101 - Behavioral Biology- Tracer Techniques