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Title: Cysteamine normalizes cerebral somatostatin level and binding in pentylenetetrazol-kindled rats

Abstract

Rats were kindled by intraperitoneal injection of pentylenetetrazol (PTZ) every 48 h. Once kindled, some of the animals received a single injection of cysteamine. Somatostatin-like immunoreactivity (SLI) and {sup 125}I-Tyr{sup 11} -somatostatin binding were measured in the frontoparietal cortex and hippocampus of the two experimental groups and the control rats. After PTZ kindling the following was observed: (1) SLI content was increased int he two areas; (2) Somatostatin receptor affinity decreased in the frontoparietal cortex and was unaltered in the hippocampus; (3) The number of somatostatin receptors decreased in the hippocampus and was unaltered in the frontoparietal cortex. Cysteamine, an agent which depletes brain somatostatin and suppresses kindled seizures in PTZ-treated rats, revered the altered SLI levels and binding in these rats.

Authors:
; ; ;  [1]
  1. Univ. of Alcala de Henares, Madrid (Spain)
Publication Date:
OSTI Identifier:
6994816
Resource Type:
Journal Article
Journal Name:
Life Sciences; (USA)
Additional Journal Information:
Journal Volume: 45:25; Journal ID: ISSN 0024-3205
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; CYSTAMINE; BIOCHEMICAL REACTION KINETICS; SOMATOSTATIN; BIOSYNTHESIS; AFFINITY; BRAIN; INTRAPERITONEAL INJECTION; IODINE 125; RATS; RECEPTORS; SECRETION; AMINES; ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; DAYS LIVING RADIOISOTOPES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; INJECTION; INTAKE; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; KINETICS; MAMMALS; MEMBRANE PROTEINS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; PROTEINS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; REACTION KINETICS; RODENTS; SYNTHESIS; VERTEBRATES; 550201* - Biochemistry- Tracer Techniques

Citation Formats

Perez-Ozo, E, Lopez-Ruiz, M P, Gonzalez-Guijarro, L, and Arilla, E. Cysteamine normalizes cerebral somatostatin level and binding in pentylenetetrazol-kindled rats. United States: N. p., 1989. Web. doi:10.1016/0024-3205(89)90010-6.
Perez-Ozo, E, Lopez-Ruiz, M P, Gonzalez-Guijarro, L, & Arilla, E. Cysteamine normalizes cerebral somatostatin level and binding in pentylenetetrazol-kindled rats. United States. https://doi.org/10.1016/0024-3205(89)90010-6
Perez-Ozo, E, Lopez-Ruiz, M P, Gonzalez-Guijarro, L, and Arilla, E. 1989. "Cysteamine normalizes cerebral somatostatin level and binding in pentylenetetrazol-kindled rats". United States. https://doi.org/10.1016/0024-3205(89)90010-6.
@article{osti_6994816,
title = {Cysteamine normalizes cerebral somatostatin level and binding in pentylenetetrazol-kindled rats},
author = {Perez-Ozo, E and Lopez-Ruiz, M P and Gonzalez-Guijarro, L and Arilla, E},
abstractNote = {Rats were kindled by intraperitoneal injection of pentylenetetrazol (PTZ) every 48 h. Once kindled, some of the animals received a single injection of cysteamine. Somatostatin-like immunoreactivity (SLI) and {sup 125}I-Tyr{sup 11} -somatostatin binding were measured in the frontoparietal cortex and hippocampus of the two experimental groups and the control rats. After PTZ kindling the following was observed: (1) SLI content was increased int he two areas; (2) Somatostatin receptor affinity decreased in the frontoparietal cortex and was unaltered in the hippocampus; (3) The number of somatostatin receptors decreased in the hippocampus and was unaltered in the frontoparietal cortex. Cysteamine, an agent which depletes brain somatostatin and suppresses kindled seizures in PTZ-treated rats, revered the altered SLI levels and binding in these rats.},
doi = {10.1016/0024-3205(89)90010-6},
url = {https://www.osti.gov/biblio/6994816}, journal = {Life Sciences; (USA)},
issn = {0024-3205},
number = ,
volume = 45:25,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 1989},
month = {Sun Jan 01 00:00:00 EST 1989}
}