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Title: Interferon. beta. /sub 2//B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells

Abstract

One of the oldest and most preserved of the homeostatic responses of the body to injury is the acute phase protein response associated with inflammation. The liver responds to hormone-like mediators by the increased synthesis of a series of plasma proteins called acute phase reactants. In these studies, the authors examined the relationship of hepatocyte-stimulating factor derived from peripheral blood monocytes to interferon ..beta../sub 2/ (IFN-..beta../sub 2/), which has been cloned. Antibodies raised against fibroblast-derived IFN-..beta.. having neutralizing activity against both IFN-..beta../sub 1/ and ..beta../sub 2/ inhibited the major hepatocyte-stimulating activity derived from monocytes. Fibroblast-derived mediator elicited the identical stimulated response in human HepG2 cells and primary rat hepatocytes as the monocyte cytokine. Finally, recombinant-derived human B-cell stimulatory factor type 2 (IFN-..beta../sub 2/) from Escherichia coli induced the synthesis of all major acute phase proteins studied in human hepatoma HepG2 and primary rat hepatocyte cultures. These data demonstrate that monocyte-derived hepatocyte-stimulating factor and IFN-..beta../sub 2/ share immunological and functional identity and that IFN-..beta../sub 2/, also known as B-cell stimulatory factor and hybridoma plasmacytoma growth factor, has the hepatocyte as a major physiologic target and thereby is essential in controlling the hepatic acute phase response.

Authors:
; ; ; ;
Publication Date:
Research Org.:
McMaster Univ., Hamilton, ON (Canada)
OSTI Identifier:
6994629
Resource Type:
Journal Article
Journal Name:
Proc. Natl. Acad. Sci. U.S.A.; (United States)
Additional Journal Information:
Journal Volume: 84:20
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; INFLAMMATION; GENETICS; PROTEINS; GENE REGULATION; ANTIBODIES; FIBROBLASTS; IMMUNITY; INJURIES; INTERFERON; LIVER CELLS; LYMPHOCYTES; LYMPHOKINES; MAN; MONOCYTES; ANIMAL CELLS; ANIMALS; BIOLOGICAL MATERIALS; BIOLOGY; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; GROWTH FACTORS; LEUKOCYTES; MAMMALS; MATERIALS; MITOGENS; ORGANIC COMPOUNDS; PATHOLOGICAL CHANGES; PRIMATES; SOMATIC CELLS; SYMPTOMS; VERTEBRATES; 550400* - Genetics

Citation Formats

Gauldie, J, Richards, C, Harnish, D, Lansdorp, P, and Baumann, H. Interferon. beta. /sub 2//B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. United States: N. p., 1987. Web. doi:10.1073/pnas.84.20.7251.
Gauldie, J, Richards, C, Harnish, D, Lansdorp, P, & Baumann, H. Interferon. beta. /sub 2//B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. United States. https://doi.org/10.1073/pnas.84.20.7251
Gauldie, J, Richards, C, Harnish, D, Lansdorp, P, and Baumann, H. 1987. "Interferon. beta. /sub 2//B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells". United States. https://doi.org/10.1073/pnas.84.20.7251.
@article{osti_6994629,
title = {Interferon. beta. /sub 2//B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells},
author = {Gauldie, J and Richards, C and Harnish, D and Lansdorp, P and Baumann, H},
abstractNote = {One of the oldest and most preserved of the homeostatic responses of the body to injury is the acute phase protein response associated with inflammation. The liver responds to hormone-like mediators by the increased synthesis of a series of plasma proteins called acute phase reactants. In these studies, the authors examined the relationship of hepatocyte-stimulating factor derived from peripheral blood monocytes to interferon ..beta../sub 2/ (IFN-..beta../sub 2/), which has been cloned. Antibodies raised against fibroblast-derived IFN-..beta.. having neutralizing activity against both IFN-..beta../sub 1/ and ..beta../sub 2/ inhibited the major hepatocyte-stimulating activity derived from monocytes. Fibroblast-derived mediator elicited the identical stimulated response in human HepG2 cells and primary rat hepatocytes as the monocyte cytokine. Finally, recombinant-derived human B-cell stimulatory factor type 2 (IFN-..beta../sub 2/) from Escherichia coli induced the synthesis of all major acute phase proteins studied in human hepatoma HepG2 and primary rat hepatocyte cultures. These data demonstrate that monocyte-derived hepatocyte-stimulating factor and IFN-..beta../sub 2/ share immunological and functional identity and that IFN-..beta../sub 2/, also known as B-cell stimulatory factor and hybridoma plasmacytoma growth factor, has the hepatocyte as a major physiologic target and thereby is essential in controlling the hepatic acute phase response.},
doi = {10.1073/pnas.84.20.7251},
url = {https://www.osti.gov/biblio/6994629}, journal = {Proc. Natl. Acad. Sci. U.S.A.; (United States)},
number = ,
volume = 84:20,
place = {United States},
year = {Thu Oct 01 00:00:00 EDT 1987},
month = {Thu Oct 01 00:00:00 EDT 1987}
}