Protection against hyperoxia by serum from endotoxin treated rats: absence of superoxide dismutase induction

Journal Article · Fri Jan 01 00:00:00 EST 1988 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-187-1-RC1· OSTI ID:6993500

Berg, J T; Smith, R M

Endotoxin greatly reduces lung injury and pleural effusions in adult rats exposed to normobaric hyperoxia (> 98% oxygen for 60 hours). This study reports that serum from endotoxin treated donor rats protects serum recipients against hyperoxic lung injury without altering lung superoxide dismutase (SOD) activity. Rats pretreated with endotoxin alone were protected and exhibited an increase in lung SOD activity as previously reported by others. Protection by serum was not due to the transfer of residual endotoxin or SOD. These results show, that protection from oxygen toxicity can occur in rats without an increase in lung SOD and suggest that a serum factor may be involved.

• Research Organization: Univ. of Hawaii, Honolulu (USA)
• OSTI ID: 6993500
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Vol. 187:1, Issue 1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ENDOTOXINS
BIOLOGICAL EFFECTS
OXYGEN
TOXICITY
BLOOD SERUM
LUNGS
RATS
SUPEROXIDE DISMUTASE
ANIMALS
ANTIGENS
BODY
ELEMENTS
ENZYMES
MAMMALS
MATERIALS
NONMETALS
ORGANS
OXIDOREDUCTASES
RESPIRATORY SYSTEM
RODENTS
TOXIC MATERIALS
TOXINS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology