Preliminary results of a phase I/II study of sodium pentosanpolysulfate in the treatment of chronic radiation-induced proctitis

Journal Article · Thu Feb 01 00:00:00 EST 1990 · American Journal of Clinical Oncology; (USA)

DOI:https://doi.org/10.1097/00000421-199002000-00008· OSTI ID:6992503

Grigsby, P W; Pilepich, M V; Parsons, C L ^[1]

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1. Washington Univ. School of Medicine, St. Louis, MO (USA)

This is a report of a phase I/II study of 13 patients treated with sodium pentosanpolysulfate (PPS) for chronic radiation-induced proctitis. A complete response was obtained in 82%, a partial response occurred in 9%, and 9% failed to respond to therapy. No significant toxicity was observed. It is concluded that PPS is an effective treatment for chronic radiation-induced proctitis and a phase III randomized, double-blind study of PPS versus placebo is planned.

• OSTI ID: 6992503
• Journal Information: American Journal of Clinical Oncology; (USA), Vol. 13:1; ISSN 0277-3732
• Country of Publication: United States
• Language: English

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