Radiation exposure and chromosome abnormalities. Human cytogenetic studies at the National Institute of Radiological Sciences, Japan, 1963-1988

Journal Article · Thu Mar 01 00:00:00 EST 1990 · Cancer Genetics and Cytogenetics; (USA)

DOI:https://doi.org/10.1016/0165-4608(90)90062-F· OSTI ID:6992487

Ishihara, T; Kohno, S; Minamihisamatsu, M ^[1]

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1. National Institute of Radiological Sciences, Chiba (Japan)

The results of human cytogenetic studies performed at the National Institute of Radiological Sciences (NIRS), Chiba, Japan for about 25 years are described. The studies were pursued primarily under two major projects: one involving people exposed to radiation under various conditions and the other involving patients with malignant diseases, especially leukemias. Whereas chromosome abnormalities in radiation-exposed people are excellent indicators of radiation exposure, their behavior in bone marrow provide useful information for a better understanding of chromosome abnormalities in leukemias and related disorders. The role of chromosome abnormalities in the genesis and development of leukemia and related disorders is considered, suggesting a view for future studies in this field.

• OSTI ID: 6992487
• Journal Information: Cancer Genetics and Cytogenetics; (USA), Vol. 45:1; ISSN 0165-4608
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHROMOSOMAL ABERRATIONS
RADIOINDUCTION
LEUKEMIA
BONE MARROW
JAPAN
KARYOTYPE
NUCLEAR WEAPONS
RADIATION INJURIES
RISK ASSESSMENT
ANIMAL TISSUES
ASIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
IMMUNE SYSTEM DISEASES
INJURIES
MUTATIONS
NEOPLASMS
ORGANS
RADIATION EFFECTS
TISSUES
WEAPONS
560151* - Radiation Effects on Animals- Man