Influence of fraction size in radiotherapy on the late normal tissue reaction. I. Comparison of the effects of daily and once-a-week fractionation on human skin

Journal Article · Tue May 01 00:00:00 EDT 1984 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(84)90289-X· OSTI ID:6980858

Turesson, I; Notter, G

A comparison of the normal tissue reactions to daily and once-a-week fractionation was performed on postoperatively irradiated bilateral parasternal fields in patients with breast cancer. Both schedules resulted in identical acute skin erythema and pigmentation. However, the development of telangiectasia was significantly more pronounced after once-a-week fractionation. These findings imply that the Cumulative Radiation Effect (CRE) formula has to be modified. The slope of the iso-effect dose versus number of fractions was 0.24 for acute skin reactions and estimated to be about 0.34 for late skin reactions at a dose level equivalent to 46 Gy in 2 Gy fractions with conventional fractionation.

• Research Organization: Univ. of Goteborg, Sweden
• OSTI ID: 6980858
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 10:5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
ERYTHEMA
RADIOINDUCTION
RADIOTHERAPY
SIDE EFFECTS
SKIN
CUMULATIVE RADIATION EFFECTS
DELAYED RADIATION EFFECTS
TELANGIECTASIS
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
FRACTIONATED IRRADIATION
PATIENTS
X RADIATION
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DATA
DISEASES
ELECTROMAGNETIC RADIATION
INFORMATION
IONIZING RADIATIONS
IRRADIATION
MEDICINE
NUCLEAR MEDICINE
NUMERICAL DATA
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
SKIN DISEASES
SYMPTOMS
THERAPY
VASCULAR DISEASES
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)