Toxicology and metabolism of nickel compounds. Progress report, December 1, 1983-November 30, 1984
The toxicology of nickel compounds (e.g., NiCl/sub 2/, Ni/sub 3/S/sub 2/, Ni(CO)/sub 4/) was investigated in rats. The following new knowledge was acquired: (1) renal cytosol from /sup 63/NiCl/sub 2/-treated rats contains at least ten /sup 63/Ni-binding proteins and polypeptides with molecular weights ranging from 168,000 to <4,000 daltons; (2) parenteral administration of NiCl/sub 2/ to rats transiently diminishes hepatic concentrations of reduced and oxidized glutathione and enhances lipid peroxidation; (3) tetraethylenepentamine is equally effective as diethyldithiocarbamate as an antidote for acute Ni(CO)/sub 4/ poisoning in rats; (4) Ni(II)-induction of heme oxygenase activity in rat kidney is sustained for only 3 days of repeated treatments and thereafter gradually decreases, indicating adaptive tolerance for Ni(II) toxicity; (5) carcinogenesis bioassays of 17 nickel compounds by ir administration to rats demonstrate close correlation between the induction of erythrocytosis at 1 to 4 months post-injection and the subsequent incidence of renal cancers; (6) immunoreactive erythropoietin concentration is increased in kidney extracts of rats following ir injection of Ni/sub 3/S/sub 2/, supporting the role of erythropoietin in Ni/sub 3/S/sub 2/-induced erythrocytosis; (7) arteriosclerotic lesions in Ni/sub 3/S/sub 2/-treated rats can be visualized by focal fluorescence of hematoporphyrin derivative injected iv 24 hours prior to necropsy; and (8) marked hypernickelemia is a consistent finding in patients with endstage renal disease receiving chronic hemodialysis treatment. 13 references.
- Research Organization:
- Connecticut Univ., Farmington (USA). School of Medicine
- DOE Contract Number:
- AC02-76EV03140
- OSTI ID:
- 6979885
- Report Number(s):
- DOE/EV/03140-8; ON: DE84014919
- Resource Relation:
- Other Information: Portions are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
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NICKEL COMPOUNDS
TOXICITY
CARCINOGENESIS
ENZYME ACTIVITY
KIDNEYS
LIVER
RATS
ANIMALS
BODY
DIGESTIVE SYSTEM
GLANDS
MAMMALS
ORGANS
PATHOGENESIS
RODENTS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)