Assignment of the phosducin (PDC) gene to human chromosome 1q25-1q32. 1 by somatic cell hybridization and in situ hybridization

Journal Article · Mon Nov 01 00:00:00 EST 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1490· OSTI ID:6975791

Sparkes, R S; Kojis, T; Klisak, I; Heinzmann, C; Bateman, J B ^[1]; Lee, R H ^[2]; Shinohara, T ^[3]; Craft, C M ^[4]

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1. Jules Stein Eye Institute, Los Angeles, CA (United States)
2. Univ. of California Developmental Neurology Lab., Sepulveda, CA (United States)
3. National Eye Institute, Bethesda, MD (United States)
4. Univ. of Texas Southwestern Medical Center, Dallas, TX (United States)

Phosducin is a soluble photoreceptor phosphoprotein that probably modulates phototransduction in the retina and thus qualifies as a potential candidate gene for retinitis pigmentosa. Using both human/mouse somatic cell hybrids and in situ hybridization to human metaphase chromosomes, the authors have mapped this gene to chromosome 1q25-1q32.1. 18 refs., 2 figs.

• OSTI ID: 6975791
• Journal Information: Genomics; (United States), Vol. 18:2; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
HUMAN CHROMOSOME 1
GENETIC MAPPING
PHOSPHOPROTEINS
GENES
RECEPTORS
RETINA
BODY
BODY AREAS
CHROMOSOMES
EYES
FACE
HEAD
HUMAN CHROMOSOMES
MAPPING
MEMBRANE PROTEINS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
SENSE ORGANS
550400* - Genetics