Uptake and distribution of /sup 14/C during and following exposure to (/sup 14/C)methyl isocyanate
Guinea pigs were exposed to (/sup 14/C)methyl isocyanate (/sup 14/CH/sub 3/-NCO, /sup 14/C MIC) for periods of 1 to 6 hr at concentrations of 0.5 to 15 ppm. Arterial blood samples taken during exposure revealed immediate and rapid uptake of /sup 14/C. Clearance of /sup 14/C was then gradual over a period of 3 days. Similarly /sup 14/C was present in urine and bile immediately following exposure, and clearance paralleled that observed in blood. Guinea pigs fitted with a tracheal cannula and exposed while under anesthesia showed a reduced /sup 14/C uptake in blood indicating that most of the /sup 14/C MIC uptake in normal guinea pigs occurred from retention of this agent in the upper respiratory tract passages. In exposed guinea pigs /sup 14/C was distributed to all examined tissues. In pregnant female mice similarly exposed to /sup 14/C MIC, /sup 14/C was observed in all tissues examined following exposure including the uterus, placenta, and fetus. While the form of /sup 14/C distributed in blood and tissues has not yet been identified, these findings may help to explain the toxicity of MIC or MIC reaction products on organs other than the respiratory tract, as noted by several investigators.
- Research Organization:
- Univ. of Pittsburgh, Pennsylvania (USA)
- OSTI ID:
- 6970990
- Journal Information:
- Toxicol. Appl. Pharmacol.; (United States), Vol. 94:1
- Country of Publication:
- United States
- Language:
- English
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CYANATES
METABOLISM
TISSUE DISTRIBUTION
TOXICITY
BILE
CARBON 14 COMPOUNDS
CLEARANCE
GLUTATHIONE
GUINEA PIGS
RESPIRATORY SYSTEM
TRACER TECHNIQUES
ANIMALS
BIOLOGICAL MATERIALS
BODY FLUIDS
CARBONIC ACID DERIVATIVES
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DRUGS
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LABELLED COMPOUNDS
MAMMALS
MATERIALS
NITROGEN COMPOUNDS
ORGANIC COMPOUNDS
PEPTIDES
POLYPEPTIDES
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RADIOPROTECTIVE SUBSTANCES
RODENTS
VERTEBRATES
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