Is a decrease in cyclic AMP a necessary and sufficient signal for maturation of amphibian oocytes
Acetylcholine rapidly lowered the intracellular levels of cyclic AMP in stage 5 and 6 Xenopus laevis oocytes. Acetylcholine alone did not induce oocyte maturation, though it did accelerate maturation induced by progesterone. The effect of acetylcholine on oocyte maturation was independent of extracellular calcium concentration. Adenosine increased cyclic AMP and abolished the progesterone-induced decrease in cyclic AMP levels in follicles and in denuded oocytes. This effect of adenosine was blocked by the Ra purinergic receptor antagonist, theophylline. Despite those effects, adenosine alone induced maturation in stage 6 oocytes and accelerated progesterone-induced maturation in both stage 5 and 6 cells. Adenosine also induced a significant increase in the rate of /sup 45/Ca efflux from oocytes in the presence and the absence of external calcium. We suggest that the activation of cell surface receptors involved in the release of calcium from cellular stores may induce or accelerate oocyte maturation independently of small changes in intracellular cyclic AMP concentration.
- Research Organization:
- Tel Aviv Univ. (Israel)
- OSTI ID:
- 6970796
- Journal Information:
- Dev. Biol.; (United States), Vol. 127:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ACETYLCHOLINE
BIOLOGICAL EFFECTS
AMP
BIOSYNTHESIS
OOCYTES
CELL DIFFERENTIATION
ADENOSINE
BIOCHEMICAL REACTION KINETICS
CALCIUM
CALCIUM 45
EGTA
FROGS
PROGESTERONE
RECEPTORS
TRACER TECHNIQUES
ALCOHOLS
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
AMINES
AMMONIUM COMPOUNDS
AMPHIBIANS
ANIMALS
AQUATIC ORGANISMS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CALCIUM ISOTOPES
CARBOXYLIC ACIDS
CHELATING AGENTS
DAYS LIVING RADIOISOTOPES
DRUGS
ELEMENTS
ESTERS
EVEN-ODD NUCLEI
GERM CELLS
GLYCOLS
HORMONES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
KETONES
KINETICS
MEMBRANE PROTEINS
METALS
NEUROREGULATORS
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
PARASYMPATHOMIMETICS
PREGNANES
PROTEINS
QUATERNARY COMPOUNDS
RADIOISOTOPES
REACTION KINETICS
RIBOSIDES
STEROID HORMONES
STEROIDS
SYNTHESIS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques