Double tracer autoradiographic method for sequential evaluation of regional cerebral perfusion

Journal Article · Sun Jan 01 00:00:00 EST 1989 · American Journal of Physiologic Imaging; (USA)

OSTI ID:6969390

Matsuda, H; Tsuji, S; Oba, H; Kinuya, K; Terada, H; Sumiya, H; Shiba, K; Mori, H; Hisada, K; Maeda, T ^[1]

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1. Kanazawa Univ. (Japan)

A new double tracer autoradiographic method for the sequential evaluation of altered regional cerebral perfusion in the same animal is presented. This method is based on the sequential injection of two tracers, {sup 99m}Tc-hexamethylpropyleneamine oxime and N-isopropyl-({sup 125}I)p-iodoamphetamine. This method is validated in the assessment of brovincamine effects on regional cerebral perfusion in an experimental model of chronic brain ischemia in the rat. The drug enhanced perfusion recovery in low-flow areas, selectively in surrounding areas of infarction. The results suggest that this technique is of potential use in the study of neuropharmacological effects applied during the experiment.

• OSTI ID: 6969390
• Journal Information: American Journal of Physiologic Imaging; (USA), Vol. 4:4; ISSN 0885-8276
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
AUTORADIOGRAPHY
ISCHEMIA
DIAGNOSIS
RADIOPHARMACEUTICALS
EVALUATION
AMPHETAMINES
CEREBRAL CORTEX
IODINE 125
ISOMERIC NUCLEI
OXIMES
PERFUSED ORGANS
RATS
TECHNETIUM 99
VASODILATORS
AMINES
ANALEPTICS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CEREBRUM
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIOISOTOPES
RODENTS
SYMPATHOMIMETICS
TECHNETIUM ISOTOPES
VASCULAR DISEASES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics