Postvaccinal sarcomas in the cat: epidemiology and electron probe microanalytical identification of aluminum
- Department of Pathobiology, School of Medicine, University of Pennsylvania, PA (United States)
An increase in fibrosarcomas in a biopsy population of cats in the Pennsylvania area appears to be related to the increased vaccination of cats following enactment of a mandatory rabies vaccination law. The majority of fibrosarcomas arose in sites routinely used by veterinarians for vaccination, and 42 of 198 tumors were surrounded by lymphocytes and macrophages containing foreign material identical to that previously described in postvaccinal inflammatory injection site reactions. Some of the vaccines used have aluminum-based adjuvants, and macrophages surrounding three tumors contained aluminum oxide identified by electron probe microanalysis and imaged by energy-filtered electron microscopy. Persistence of inflammatory and immunological reactions associated with aluminum may predispose the cat to a derangement of its fibrous connective tissue repair response, leading to neoplasia.
- OSTI ID:
- 6968155
- Journal Information:
- Cancer Research; (United States), Vol. 52:19; ISSN 0008-5472
- Country of Publication:
- United States
- Language:
- English
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ALUMINIUM
CARCINOGENESIS
CATS
SARCOMAS
BIOPSY
ELECTRON MICROPROBE ANALYSIS
LYMPHOCYTES
MACROPHAGES
PENNSYLVANIA
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMICAL ANALYSIS
CONNECTIVE TISSUE CELLS
DEVELOPED COUNTRIES
DIAGNOSTIC TECHNIQUES
DISEASES
ELEMENTS
LEUKOCYTES
MAMMALS
MATERIALS
METALS
MICROANALYSIS
NEOPLASMS
NONDESTRUCTIVE ANALYSIS
NORTH AMERICA
PATHOGENESIS
PHAGOCYTES
SOMATIC CELLS
USA
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology