Oat cell carcinoma of esophagus: a report of six British patients with a review of the literature

Doherty, M A; McIntyre, M; Arnott, S J

doi:10.1016/0360-3016(84)90421-8

Title: Oat cell carcinoma of esophagus: a report of six British patients with a review of the literature

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Abstract

This paper presents 6 British patients with a diagnosis of oat cell carcinoma of the esophagus. Sixty-six patients have previously been reported in the literature, the majority (30) being British. Approximately two-thirds of these tumors have been reported as pure oat cell carcinoma of the esophagus. Four other histological patterns have been described: oat cell carcinoma with squamous carcinoma in situ; oat cell carcinoma with squamous carcinoma; oat cell carcinoma with adenocarcinoma; and oat cell carcinoma with carcinoid differentiation. A preponderance of males has also been noted, although this series shows a 2:1 female:male ratio. The tumor arises most commonly in the mid or lower esophagus. The cell of origin of these tumors is considered to be the Kulchitsky or APUD cell of neuroectodermal derivation. They may show neurosecretory granules on electron microsopy. Polypeptides have been identified within the tumor cells. One previous report describes a patient with primary oat cell carcinoma of the esophagus and hypercalcemia. A patient with the syndrome of inappropriate anti-diuretic hormone secretion is described in this paper. Survival is poor following radiotherapy, with a median survival of 3 months in this series. On reviewing the records of the Radiation Oncology Unit in Edinburgh, no patientmore »« less

Authors:: Doherty, M A; McIntyre, M; Arnott, S J

Publication Date:: Sun Jan 01 00:00:00 EST 1984

Research Org.:: Western General Hospital, Edinburgh, Scotland

OSTI Identifier:: 6964680

Resource Type:: Journal Article

Journal Name:: Int. J. Radiat. Oncol., Biol. Phys.; (United States)

Additional Journal Information:: Journal Volume: 12:1

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; CARCINOMAS; PATHOLOGY; RADIOTHERAPY; EVALUATION; ESOPHAGUS; HARD X RADIATION; PATIENTS; BODY; DIGESTIVE SYSTEM; DISEASES; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; ORGANS; RADIATIONS; RADIOLOGY; THERAPY; X RADIATION; 550603* - Medicine- External Radiation in Therapy- (1980-); 550900 - Pathology

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                    Doherty, M A, McIntyre, M, and Arnott, S J. Oat cell carcinoma of esophagus: a report of six British patients with a review of the literature.  United States: N. p., 1984. 
        Web.  doi:10.1016/0360-3016(84)90421-8.

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                    Doherty, M A, McIntyre, M, & Arnott, S J. Oat cell carcinoma of esophagus: a report of six British patients with a review of the literature.  United States.  https://doi.org/10.1016/0360-3016(84)90421-8

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                    Doherty, M A, McIntyre, M, and Arnott, S J. 1984.  
        "Oat cell carcinoma of esophagus: a report of six British patients with a review of the literature".  United States.  https://doi.org/10.1016/0360-3016(84)90421-8.

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@article{osti_6964680,

  title        = {Oat cell carcinoma of esophagus: a report of six British patients with a review of the literature},

  author       = {Doherty, M A and McIntyre, M and Arnott, S J},

  abstractNote = {This paper presents 6 British patients with a diagnosis of oat cell carcinoma of the esophagus. Sixty-six patients have previously been reported in the literature, the majority (30) being British. Approximately two-thirds of these tumors have been reported as pure oat cell carcinoma of the esophagus. Four other histological patterns have been described: oat cell carcinoma with squamous carcinoma in situ; oat cell carcinoma with squamous carcinoma; oat cell carcinoma with adenocarcinoma; and oat cell carcinoma with carcinoid differentiation. A preponderance of males has also been noted, although this series shows a 2:1 female:male ratio. The tumor arises most commonly in the mid or lower esophagus. The cell of origin of these tumors is considered to be the Kulchitsky or APUD cell of neuroectodermal derivation. They may show neurosecretory granules on electron microsopy. Polypeptides have been identified within the tumor cells. One previous report describes a patient with primary oat cell carcinoma of the esophagus and hypercalcemia. A patient with the syndrome of inappropriate anti-diuretic hormone secretion is described in this paper. Survival is poor following radiotherapy, with a median survival of 3 months in this series. On reviewing the records of the Radiation Oncology Unit in Edinburgh, no patient with oat cell carcinoma of the esophagus was reported before 1972. This suggests that awareness of this tumor is increasing and, although rare, its incidence is greater than previously reported.},

  doi          = {10.1016/0360-3016(84)90421-8},

  url          = {https://www.osti.gov/biblio/6964680},
  journal      = {Int. J. Radiat. Oncol., Biol. Phys.; (United States)},
number       = ,

  volume       = 12:1,

  place        = {United States},

  year         = {Sun Jan 01 00:00:00 EST 1984},

  month        = {Sun Jan 01 00:00:00 EST 1984}

}

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