Pathogenesis of rheumatoid arthritis and the immune response

Journal Article · Mon Aug 01 00:00:00 EDT 1983 · Semin. Arthritis Rheum.; (United States)

DOI:https://doi.org/10.1016/0049-0172(83)90027-6· OSTI ID:6963360

Scheinberg, M A

The interrelationship among lymphocytes, macrophages, and neutrophils appears to be an important aspect of the synovial inflammation that is characteristic of rheumatoid arthritis. In a study comparing gold sodium aurothiomalate (GST) with auranofin (Au), an orally absorbed compound, both appeared to inhibit the disease process and no difference between parenteral and oral administration was observed. Another study involved two groups of nine patients with severe rheumatoid arthritis. One group underwent plasmapheresis. The second group underwent total lymphoid irradiation. Both agents appeared to inhibit the disease process. Plasmapheresis was better tolerated that irradiation.

• OSTI ID: 6963360
• Journal Information: Semin. Arthritis Rheum.; (United States), Vol. 13:1 Suppl 1
• Country of Publication: United States
• Language: English

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