Assessing the risks to young children of three effects associated with elevated blood-lead levels
Formal risk assessments were conducted as part of the US Environmental Protection Agency's current review of the primary National Ambient Air Quality Standard for lead. The assessments focused on three potentially adverse effects of exposure to lead in children from birth through the seventh birthday: erythrocyte protoporphyrin (EP) elevation, hemoglobin (Hb) decrement, and intelligence quotient (IQ) effect. The same general strategy was followed in all three cases: for two levels of each effect, probability distributions over population response rate were estimated at a series of blood-lead (PbB) levels. These distributions were estimated from data in the case of EP elevation and from expert judgements in the cases of Hb decrement and IQ effect. Although of interest in their own right, these estimates were combined with PbB distributions to yield probability distributions over the estimated percentages of children experiencing the particular health effects. 15 refs., 24 figs., 24 tabs.
- Research Organization:
- Argonne National Lab., IL (USA)
- DOE Contract Number:
- W-31-109-ENG-38
- OSTI ID:
- 6956462
- Report Number(s):
- ANL/AA-32; ON: DE87004219
- Resource Relation:
- Other Information: Portions of this document are illegible in microfiche products. Original copy available until stock is exhausted
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
LEAD
HEALTH HAZARDS
RISK ASSESSMENT
BEHAVIOR
BLOOD CHEMISTRY
CHILDREN
DOSE-RESPONSE RELATIONSHIPS
EPIDEMIOLOGY
EXPERIMENTAL DATA
HEMOGLOBIN
INFANTS
PORPHYRINS
STATISTICAL DATA
AGE GROUPS
CARBOXYLIC ACIDS
DATA
ELEMENTS
GLOBIN
HAZARDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INFORMATION
METALS
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PROTEINS
560300* - Chemicals Metabolism & Toxicology
550100 - Behavioral Biology
550900 - Pathology