Radioimmunotherapy with alpha-particle-emitting immunoconjugates
Alpha particles are energetic short-range ions whose higher linear energy transfer produces extreme cytotoxicity. An ..cap alpha..-particle-emitting radioimmunoconjugate consisting of a bismuth-212-labeled monoclonal immunoglobulin M specific for the murine T cell/neuroectodermal surface antigen Thy 1.2 was prepared. Analysis in vitro showed that the radioimmunoconjugate was selectively cytotoxic to a Thy 1.2/sup +/ EL-4 murine tumor cell line. Approximately three bismuth-212-labeled immunoconjugates per target cell reduced the uptake of (/sup 3/H)thymidine by the EL-4 target cells to background levels. Mice inoculated intraperitoneally with EL-4 cells were cured of their ascites after intraperitoneal injection of 150 microcuries of the antigen-specific radioimmunoconjugate, suggesting a possible role for such conjugates in intracavitary cancer therapy. 18 references, 3 figures.
- Research Organization:
- Harvard Medical School, Boston, MA (USA)
- DOE Contract Number:
- FG02-86ER60460; W-31-109-ENG-38
- OSTI ID:
- 6954800
- Journal Information:
- Science (Washington, D.C.); (United States), Vol. 240
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ASCITES
RADIOIMMUNOTHERAPY
BISMUTH 212
LABELLED COMPOUNDS
IMMUNOGLOBULINS
MONOCLONAL ANTIBODIES
ALPHA PARTICLES
MICE
ALPHA DECAY RADIOISOTOPES
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BISMUTH ISOTOPES
CHARGED PARTICLES
GLOBULINS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IMMUNOLOGY
ISOTOPES
MAMMALS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PROTEINS
RADIOIMMUNOLOGY
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RODENTS
SYMPTOMS
THERAPY
VERTEBRATES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)