Radioimmunotherapy with alpha-particle-emitting immunoconjugates
Abstract
Alpha particles are energetic short-range ions whose higher linear energy transfer produces extreme cytotoxicity. An ..cap alpha..-particle-emitting radioimmunoconjugate consisting of a bismuth-212-labeled monoclonal immunoglobulin M specific for the murine T cell/neuroectodermal surface antigen Thy 1.2 was prepared. Analysis in vitro showed that the radioimmunoconjugate was selectively cytotoxic to a Thy 1.2/sup +/ EL-4 murine tumor cell line. Approximately three bismuth-212-labeled immunoconjugates per target cell reduced the uptake of (/sup 3/H)thymidine by the EL-4 target cells to background levels. Mice inoculated intraperitoneally with EL-4 cells were cured of their ascites after intraperitoneal injection of 150 microcuries of the antigen-specific radioimmunoconjugate, suggesting a possible role for such conjugates in intracavitary cancer therapy. 18 references, 3 figures.
- Authors:
- Publication Date:
- Research Org.:
- Harvard Medical School, Boston, MA (USA)
- OSTI Identifier:
- 6954800
- DOE Contract Number:
- FG02-86ER60460; W-31-109-ENG-38
- Resource Type:
- Journal Article
- Journal Name:
- Science (Washington, D.C.); (United States)
- Additional Journal Information:
- Journal Volume: 240
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; ASCITES; RADIOIMMUNOTHERAPY; BISMUTH 212; LABELLED COMPOUNDS; IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; ALPHA PARTICLES; MICE; ALPHA DECAY RADIOISOTOPES; ANIMALS; ANTIBODIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BISMUTH ISOTOPES; CHARGED PARTICLES; GLOBULINS; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; IMMUNOLOGY; ISOTOPES; MAMMALS; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; PATHOLOGICAL CHANGES; PROTEINS; RADIOIMMUNOLOGY; RADIOISOTOPES; RADIOLOGY; RADIOTHERAPY; RODENTS; SYMPTOMS; THERAPY; VERTEBRATES; 550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)
Citation Formats
Macklis, R M, Kinsey, B M, Kassis, A L, Ferrara, J L.M., Atcher, R W, Hines, J J, Coleman, C N, Adelstein, S J, and Burakoff, S J. Radioimmunotherapy with alpha-particle-emitting immunoconjugates. United States: N. p., 1988.
Web. doi:10.1126/science.2897133.
Macklis, R M, Kinsey, B M, Kassis, A L, Ferrara, J L.M., Atcher, R W, Hines, J J, Coleman, C N, Adelstein, S J, & Burakoff, S J. Radioimmunotherapy with alpha-particle-emitting immunoconjugates. United States. https://doi.org/10.1126/science.2897133
Macklis, R M, Kinsey, B M, Kassis, A L, Ferrara, J L.M., Atcher, R W, Hines, J J, Coleman, C N, Adelstein, S J, and Burakoff, S J. 1988.
"Radioimmunotherapy with alpha-particle-emitting immunoconjugates". United States. https://doi.org/10.1126/science.2897133.
@article{osti_6954800,
title = {Radioimmunotherapy with alpha-particle-emitting immunoconjugates},
author = {Macklis, R M and Kinsey, B M and Kassis, A L and Ferrara, J L.M. and Atcher, R W and Hines, J J and Coleman, C N and Adelstein, S J and Burakoff, S J},
abstractNote = {Alpha particles are energetic short-range ions whose higher linear energy transfer produces extreme cytotoxicity. An ..cap alpha..-particle-emitting radioimmunoconjugate consisting of a bismuth-212-labeled monoclonal immunoglobulin M specific for the murine T cell/neuroectodermal surface antigen Thy 1.2 was prepared. Analysis in vitro showed that the radioimmunoconjugate was selectively cytotoxic to a Thy 1.2/sup +/ EL-4 murine tumor cell line. Approximately three bismuth-212-labeled immunoconjugates per target cell reduced the uptake of (/sup 3/H)thymidine by the EL-4 target cells to background levels. Mice inoculated intraperitoneally with EL-4 cells were cured of their ascites after intraperitoneal injection of 150 microcuries of the antigen-specific radioimmunoconjugate, suggesting a possible role for such conjugates in intracavitary cancer therapy. 18 references, 3 figures.},
doi = {10.1126/science.2897133},
url = {https://www.osti.gov/biblio/6954800},
journal = {Science (Washington, D.C.); (United States)},
number = ,
volume = 240,
place = {United States},
year = {Fri May 20 00:00:00 EDT 1988},
month = {Fri May 20 00:00:00 EDT 1988}
}