Urinary excretion of furosemide in rats with HgCl sub 2 -induced acute renal damage

Journal Article · Wed Jan 01 00:00:00 EST 1992 · Life Sciences; (United States)

DOI:https://doi.org/10.1016/0024-3205(92)90560-C· OSTI ID:6952265

Fujimura, Akio; Sudoh, Toshiaki; Ohashi, Kyoichi; Ebihara, Akio ^[1]

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1. Jichi Medical School, Tochigi (Japan)

To examine the influence of mercuric chloride (HgCl{sub 2})-induced acute renal damage on urinary excretion of furosemide, HgCl{sub 2} or its vehicle along was given intraperitoneally to Wistar rats. The following two experiments were done. Study 1: three percent body weight (b.w.) of 1% NaCl solution or furosemide in 3% b.w. of 1% NaCl solution was given orally before and after HgCl{sub 2} treatment, and an 8-hour urine was collected. Study 2: furosemide was given orally, and blood samples were obtained at 1, 2, 3, 4, 6 and 8 hours after administration. Urinary excretion of N-acetyl-{beta}-D-glucosaminidase increased, and urine volume and urinary excretions of furosemide and sodium decreased in the HgCl{sub 2}-treated rats. There were significant correlations between the urinary furosemide and its diuretic effects. Regression lines after HgCl{sub 2} were significantly different from those before treatment. The values of absorption as well as elimination rate constant were smaller, while the time to maximum concentration and the elimination half-life were longer in the HgCl{sub 2}-treated rats compared to vehicle-treated animals. These results suggest that the urinary excretion of furosemide and the responsiveness of renal tubular cells to this agent are impaired in rats with HgCl{sub 2}-induced acute renal damage.

• OSTI ID: 6952265
• Journal Information: Life Sciences; (United States), Vol. 51:19; ISSN 0024-3205
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DIURETICS
EXCRETION
MERCURY CHLORIDES
TOXICITY
TUBULES
PATHOLOGICAL CHANGES
ACUTE EXPOSURE
INTRAPERITONEAL INJECTION
METABOLISM
ORAL ADMINISTRATION
RATS
ANIMALS
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CHLORIDES
CHLORINE COMPOUNDS
CLEARANCE
DRUGS
HALIDES
HALOGEN COMPOUNDS
INJECTION
INTAKE
KIDNEYS
MAMMALS
MERCURY COMPOUNDS
MERCURY HALIDES
ORGANS
RODENTS
VERTEBRATES
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