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Title: The use of postoperative irradiation for the prevention of heterotopic bone after total hip replacement with biologic fixation (porous coated) prosthesis: An animal model

Abstract

Radiation has been shown to be effective in the prevention of heterotopic bone. The exact etiology of heterotopic bone is unknown. Total hip prosthetic devices that do not depend upon bone cement for fixation have become increasingly popular. The mechanism by which the bone forms around the prosthesis is similar to the process by which fractures heal which has been shown to be sensitive to irradiation. Using a rabbit model we have undertaken a study to investigate the effect of irradiation on the bony ingrowth on porous coated implants. Forty-five rabbits had porous coated implants surgically placed in the tibiae bilaterally. Each rabbit had one tibia randomly irradiated with 1,000 cGy in 5 fractions starting on the first post-operative day. Animals were sacrificed weekly starting 2 weeks post-operatively and the tibae were sent for pullout studies. The amount of force necessary to pullout the treated tibae was statistically less than the amount of force necessary to remove the untreated tibae at 2 weeks. From 3 weeks on there was no difference in the force necessary to remove the prosthesis from the untreated or treated tibae. Histologically, the untreated tibae showed bone formation while the treated tibae did not. Because ofmore » these results, it is suggested that the treatment of patients at risk for development of heterotopic bone be modified to only include the area between the femur and pelvis avoiding treatment of the prosthetic device.« less

Authors:
; ; ; ; ; ; ; ; ;  [1]
  1. Strong Memorial Hospital, Rochester, NY (USA)
Publication Date:
OSTI Identifier:
6945287
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics; (USA)
Additional Journal Information:
Journal Volume: 18:4; Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; TIBIA; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL MODELS; FRACTIONATED IRRADIATION; HEALING; NEOPLASMS; PROSTHESES; RABBITS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; BODY; DISEASES; IRRADIATION; MAMMALS; MEDICAL SUPPLIES; ORGANS; RADIATION EFFECTS; RECOVERY; SKELETON; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Konski, A, Weiss, C, Rosier, R, Poulter, C, Pelligrini, V, Anthony, P, Evarts, C M, Richardson, M, Henzler, M, and Rubin, P. The use of postoperative irradiation for the prevention of heterotopic bone after total hip replacement with biologic fixation (porous coated) prosthesis: An animal model. United States: N. p., 1990. Web. doi:10.1016/0360-3016(90)90408-C.
Konski, A, Weiss, C, Rosier, R, Poulter, C, Pelligrini, V, Anthony, P, Evarts, C M, Richardson, M, Henzler, M, & Rubin, P. The use of postoperative irradiation for the prevention of heterotopic bone after total hip replacement with biologic fixation (porous coated) prosthesis: An animal model. United States. https://doi.org/10.1016/0360-3016(90)90408-C
Konski, A, Weiss, C, Rosier, R, Poulter, C, Pelligrini, V, Anthony, P, Evarts, C M, Richardson, M, Henzler, M, and Rubin, P. 1990. "The use of postoperative irradiation for the prevention of heterotopic bone after total hip replacement with biologic fixation (porous coated) prosthesis: An animal model". United States. https://doi.org/10.1016/0360-3016(90)90408-C.
@article{osti_6945287,
title = {The use of postoperative irradiation for the prevention of heterotopic bone after total hip replacement with biologic fixation (porous coated) prosthesis: An animal model},
author = {Konski, A and Weiss, C and Rosier, R and Poulter, C and Pelligrini, V and Anthony, P and Evarts, C M and Richardson, M and Henzler, M and Rubin, P},
abstractNote = {Radiation has been shown to be effective in the prevention of heterotopic bone. The exact etiology of heterotopic bone is unknown. Total hip prosthetic devices that do not depend upon bone cement for fixation have become increasingly popular. The mechanism by which the bone forms around the prosthesis is similar to the process by which fractures heal which has been shown to be sensitive to irradiation. Using a rabbit model we have undertaken a study to investigate the effect of irradiation on the bony ingrowth on porous coated implants. Forty-five rabbits had porous coated implants surgically placed in the tibiae bilaterally. Each rabbit had one tibia randomly irradiated with 1,000 cGy in 5 fractions starting on the first post-operative day. Animals were sacrificed weekly starting 2 weeks post-operatively and the tibae were sent for pullout studies. The amount of force necessary to pullout the treated tibae was statistically less than the amount of force necessary to remove the untreated tibae at 2 weeks. From 3 weeks on there was no difference in the force necessary to remove the prosthesis from the untreated or treated tibae. Histologically, the untreated tibae showed bone formation while the treated tibae did not. Because of these results, it is suggested that the treatment of patients at risk for development of heterotopic bone be modified to only include the area between the femur and pelvis avoiding treatment of the prosthetic device.},
doi = {10.1016/0360-3016(90)90408-C},
url = {https://www.osti.gov/biblio/6945287}, journal = {International Journal of Radiation Oncology, Biology and Physics; (USA)},
issn = {0360-3016},
number = ,
volume = 18:4,
place = {United States},
year = {Sun Apr 01 00:00:00 EST 1990},
month = {Sun Apr 01 00:00:00 EST 1990}
}