Effects of recanalisation on global left ventricular function in acute myocardial infarction
302 patients (pts) with acute myocardial infarction (MI) were enrolled in a multicentre trial, comparing conventional treatment (C) with attempted recanalisation by intracoronary streptokinase (SK). Out of 153 pts allocated to SK 17 refused intervention. The infarct related vessel was patent in 26 pts, recanalisation was achieved in 87 out of 110 pts with an occluded vessel. Median interval between onset of symptoms and recanalization was 220 minutes. Data were analyzed according to the original treatment allocation. Left ventricular ejection fraction (LVEF) was measured by radionuclide angiography within 48 hours in 232 pts, at 2 weeks in 179 pts and after 3 months in 128 pts. Paired data both within 48 hours and at 2 weeks were available in 152 pts. Global LV function remains unchanged C between 48 hr and at 3 months. Recanalisation by earlier intracoronary SK improves global LV function at 2 weeks in inferior MI and both at 2 weeks and 3 months in anterior MI.
- Research Organization:
- Interuniversity Cardiology Institute
- OSTI ID:
- 6942347
- Report Number(s):
- CONF-850611-
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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EVALUATION
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CHEMOTHERAPY
MYOCARDIUM
BIOLOGICAL REPAIR
THERAPEUTIC USES
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL RECOVERY
BIOMEDICAL RADIOGRAPHY
BLOOD VESSELS
DOSE-RESPONSE RELATIONSHIPS
METABOLISM
RADIOCARDIOGRAPHY
THERAPY
TISSUE DISTRIBUTION
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CARDIOVASCULAR SYSTEM
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
DRUGS
ENZYMES
FUNCTIONS
HYDROLASES
MEDICINE
MUSCLES
NUCLEAR MEDICINE
ORGANS
PEPTIDE HYDROLASES
RADIOLOGY
RECOVERY
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