Nuclear medicine: Progress report for quarter ending September 30, 1986
The synthesis of two new dimethyl-branched analogues of 15-(p-iodophenyl)-3,3'-dimethylpentadecanoic acid (DMIPP) is described. Methyl-branching was introduced into the 6- and 9-positions to determine the effect of the position of dimethyl-branching on myocardial uptake and clearance kinetics in rats. The goal of these studies is to maximize heart uptake and retention and minimize blood and liver uptake. The 6,6'-dimethyl- (6,6'-DMIPP) and 9.9'-dimethyl- (9,9'-DMIPP) analogues were prepared by multi-step sequences involving successive Friedel-Crafts/Wolf Kishner reactions on thiophene. Regiospecific para-iodination using thallation and treatment with iodide provided the two new analogues. The 9,9'-(I-125)DMIPP was evaluated in rats and showed somewhat lower uptake than 3,3'-DMIPP (3.13 dose/gm at 5 min versus 4.18) and more rapid clearance (approx.30% at 1 h). In addition the heart:blood ratios were lower for the 9,9'-dimethyl isomer. These studies have demonstrated the effects of the position of dimethyl substitution on uptake and retention. 1 ref., 3 figs., 2 tabs.
- Research Organization:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 6941915
- Report Number(s):
- ORNL/TM-10294; ON: DE87005288
- Resource Relation:
- Other Information: Portions of this document are illegible in microfiche products. Original copy available until stock is exhausted
- Country of Publication:
- United States
- Language:
- English
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Nuclear medicine progress report for quarter ending December 31, 1986
Radioiodinated 15-(p-iodophenyl)-3,3-dimethylpentadecanoic acid (DMIPP): A new agent to evaluate regional myocardial fatty acid uptake
Related Subjects
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
ORGANIC IODINE COMPOUNDS
CHEMICAL PREPARATION
TISSUE DISTRIBUTION
BLOOD
CYCLASES
ELECTROPHORESIS
HEART
IMIDES
IODINE 125
KIDNEYS
LIVER
LUNGS
MONOCARBOXYLIC ACIDS
RADIOPHARMACEUTICALS
STRUCTURE-ACTIVITY RELATIONSHIPS
THYROID
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
ENZYMES
GLANDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LYASES
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIOISOTOPES
RESPIRATORY SYSTEM
SYNTHESIS
550602* - Medicine- External Radiation in Diagnostics- (1980-)
400201 - Chemical & Physicochemical Properties