Cerebral blood flow imaging with thallium-201 diethyldithiocarbamate SPECT
Thallium-201 diethyldithiocarbamate ((/sup 201/TI)DDC) was studied in humans as an agent for cerebral blood flow imaging. Brain uptake proved to be complete 90 sec after injection with no appreciable washout or redistribution for hours. Intracarotid injection suggested an almost 100% extraction during the first passage. Whole-body distribution studies demonstrated a brain uptake of 4.3% of the dose compared with 0.9% for (/sup 201/TI)chloride. No differences were found in the distribution of (/sup 201/TI)DDC versus (/sup 201/TI)chloride in other organs. After the injection of 3 mCi /sup 201/TI, good quality single photon emission computed tomographic (SPECT) images of the brain were obtained with both a rotating gamma camera and a multidetector system. In ischemic brain disease, perfusion defects were easily demonstrated. We conclude that (/sup 201/TI)DDC is a suitable radiopharmaceutical for SPECT studies of cerebral blood flow.
- Research Organization:
- Univ. of Amsterdam, The Netherlands
- OSTI ID:
- 6941710
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BRAIN
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
RADIOPHARMACEUTICALS
EVALUATION
BLOOD FLOW
DIAGNOSIS
ISCHEMIA
THALLIUM 201
UPTAKE
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HEAVY NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
THALLIUM ISOTOPES
TOMOGRAPHY
VASCULAR DISEASES
550601* - Medicine- Unsealed Radionuclides in Diagnostics