Association of senile lens and dermal changes with cumulative ultraviolet exposure
A cross-sectional prevalence survey of senile lens opacities was conducted, using as subjects white men between the ages of 40 and 70 years who had a biopsy of their facial skin within the previous 18 months. Specimens were graded by the extent of dermal elastosis seen histologically; this ordinal grading acted as a measure of cumulative solar UV exposure in this population. The men attended a clinic when they received an ophthalmic examination, including grading of the type and severity of senile lens opacity seen in each eye after mydriasis. A history of exposure to sun and other potential cataract risk factors was obtained by interview. The visual appearance of actinic damage to their facial skin was graded and recorded. The history of sun exposure was used to calculate a cumulative UVB exposure index; this index and the visual grading were tested as measures of solar UV damage against the histological elastosis grade. The three exposure measures were not found to be equivalent. The UVB exposure index was not a good predictor of either measure of skin damage after adjustment by age and susceptibility to sun damage, and may be confounded by behavioral practices which were not recorded. This visual assessment of actinic skin damage was a significant predictor of severe actinic elastosis, but also appears to be confounded by age, which was incompletely controlled by adjustment. In both cases, the best predictor of severe actinic elastosis was poor ability to tan, a measure of susceptibility to sun damage.
- Research Organization:
- Johns Hopkins Univ., Baltimore, MD (USA)
- OSTI ID:
- 6937515
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ULTRAVIOLET RADIATION
BIOLOGICAL EFFECTS
CATARACTS
CRYSTALLINE LENS
MEN
SKIN
ANIMALS
BODY
BODY AREAS
DISEASES
ELECTROMAGNETIC RADIATION
EYES
FACE
HEAD
MALES
MAMMALS
MAN
ORGANS
PRIMATES
RADIATIONS
SENSE ORGANS
SENSE ORGANS DISEASES
VERTEBRATES
551000* - Physiological Systems