Ultrastructural and functional effects of lead poisoning on adult canine myocardium: assessment of thiamin treatment

Thesis/Dissertation · Tue Jan 01 00:00:00 EST 1985

OSTI ID:6937489

Kincaid, N G

The effects of lead (Pb) poisoning on the adult canine myocardium were assessed quantitatively using stereological techniques, functional testing, and blood analyses as well as qualitatively by morphological investigation. Relative measurements using stereological techniques compared the volume fractions of cellular components of the three groups. Blood was analyzed for lead, hemoglobin, hematocrit, total erythrocytes, total leukocytes, thiamin pyrophosphate (TPP), delta-aminolevulinic acid dehydratase activity (ALAD), and zinc protoporphyrin (ZPP). The major finding of the stereological analysis was the statistically significant increase of 3.2% in myofilament volume in the Pb treated group and the significant decrease in mitochondrial volume in both the Pb treated and Pb + B/sub 1/ treated groups. A statistically significant decrease in the mitochondria/myofilament volume ratio was found in the Pb treated, but no Pb + B/sub 1/ treated group. This may indicate either a protective effect of thiamin on mitochondria or a reduced compensatory need of the myocyte to increase myofilament volume.

• Research Organization: Tennessee Univ., Knoxville (USA)
• OSTI ID: 6937489
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LEAD
BIOLOGICAL EFFECTS
TOXICITY
THIAMINE
DOGS
ELECTRON MICROSCOPY
MITOCHONDRIA
MYOCARDIUM
AMINES
ANIMALS
AZINES
AZOLES
BODY
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
ELEMENTS
HEART
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
MAMMALS
METALS
MICROSCOPY
MUSCLES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANOIDS
ORGANS
PYRIMIDINES
THIAZOLES
VERTEBRATES
VITAMIN B GROUP
VITAMINS
551000* - Physiological Systems
560300 - Chemicals Metabolism & Toxicology