Enhancement of radiation effects by acyclovir

Journal Article · Fri Aug 01 00:00:00 EDT 1986 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(86)90211-7· OSTI ID:6934522

Sougawa, M; Akagi, K; Murata, T; Kawasaki, S; Sawada, S; Yoshii, G; Tanaka, Y

Acyclovir (ACV), a new antiviral drug, was used to investigate its effect of radiosensitivity in tumors in vivo. In in vivo experiments with Sarcoma-180 transplanted into the ICR mouse and FM3A transplanted into the C/sub 3/H mouse, ACV enhanced the radiosensitivity of both tumors. In S-180, radiation effects were enhanced by treatment with 100 mg/kg of ACV from 30 min before to 60 min after irradiation. In S-180 treated by 400 mg/kg of ACV, the enhancement ratio was approximately 2.0, as evaluated by the growth delay method. In the FM3A tumor treated by 20 mg/kg of ACV, the enhancement ratio was approximately 1.3, as evaluated by tumor cure (TCD50 assay). ACV is already clinically used as an antiviral drug. Its ability to radiosensitize tumors could therefore have clinical potential when combined with radiotherapy.

• Research Organization: Kansai Medical Univ., Osaka Pref., Japan
• OSTI ID: 6934522
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 8
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIBIOTICS
RADIOSENSITIVITY EFFECTS
BIOLOGICAL RADIATION EFFECTS
IN VITRO
MICE
TUMOR CELLS
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
BIOLOGICAL EFFECTS
DRUGS
MAMMALS
RADIATION EFFECTS
RODENTS
VERTEBRATES
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture