Microvascular leakage of plasma proteins after PUVA and UVA
The transcapillary escape rate of albumin (TERalb), is a parameter of the leakage of macromolecules from the total microvasculature. In patients with psoriasis short-term PUVA treatment induces an increase in TERalb. In this study TERalb was measured in 3 groups of normal humans treated with PUVA, UVA and 8-methoxypsoralen. Treatment with PUVA and UVA caused a statistically significant increase in TERalb, whereas treatment with 8-methoxypsoralen did not induce any measurable changes. It is concluded that the UVA irradiation causes the abnormal leakage of macromolecules, whereas psoralen is not the responsible component. Furthermore the phenomenon can be elicited in normals and is not based on a preexisting psoriasis.
- Research Organization:
- Departments of Clinical Physiology and Dermatology, The Finsen Institute, Copenhagen, Denmark
- OSTI ID:
- 6933711
- Journal Information:
- J. Invest. Dermatol.; (United States), Vol. 78:4
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
QUANTITATIVE CHEMICAL ANALYSIS
ULTRAVIOLET RADIATION
BIOLOGICAL EFFECTS
CAPILLARIES
CHEMOTHERAPY
COMPARATIVE EVALUATIONS
MEASURING METHODS
PATIENTS
PERMEABILITY
PSORALEN
PSORIASIS
STATISTICS
ANTICOAGULANTS
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
CHEMICAL ANALYSIS
COUMARINS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
MATHEMATICS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PROTEINS
RADIATIONS
SKIN DISEASES
THERAPY
550200* - Biochemistry
550600 - Medicine