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Title: Quantitative assessment of growth plate activity

In the immature skeleton the physis or growth plate is the area of bone least able to withstand external forces and is therefore prone to trauma. Such trauma often leads to premature closure of the plate and results in limb shortening and/or angular deformity (varus or valgus). Active localization of bone seeking tracers in the physis makes bone scintigraphy an excellent method for assessing growth plate physiology. To be most effective, however, physeal activity should be quantified so that serial evaluations are accurate and comparable. The authors have developed a quantitative method for assessing physeal activity and have applied it ot the hip and knee. Using computer acquired pinhole images of the abnormal and contralateral normal joints, ten regions of interest are placed at key locations around each joint and comparative ratios are generated to form a growth plate profile. The ratios compare segmental physeal activity to total growth plate activity on both ipsilateral and contralateral sides and to adjacent bone. In 25 patients, ages 2 to 15 years, with angular deformities of the legs secondary to trauma, Blount's disease, and Perthes disease, this technique is able to differentiate abnormal segmental physeal activity. This is important since plate closure doesmore » not usually occur uniformly across the physis. The technique may permit the use of scintigraphy in the prediction of early closure through the quantitative analysis of serial studies.« less
Authors:
; ; ;
Publication Date:
OSTI Identifier:
6932952
Report Number(s):
CONF-840619-
Journal ID: CODEN: JNMEA; TRN: 87-008845
Resource Type:
Conference
Resource Relation:
Journal Name: J. Nucl. Med.; (United States); Journal Volume: 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
Research Org:
Alfred I. DuPont Institute, Wilmington, DE
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BONE JOINTS; INJURIES; SCINTISCANNING; AGE DEPENDENCE; CHILDREN; COMPUTER GRAPHICS; GROWTH; IMAGE PROCESSING; IMAGES; LEGS; PHYSIOLOGY; AGE GROUPS; BODY; BODY AREAS; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; LIMBS; ORGANS; PROCESSING; RADIOISOTOPE SCANNING; SKELETON 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics