skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Radioimmunoassay of tumor markers in serum of patients with renal carcinoma

Abstract

Having noted an increased serum level of TPA and CEA in patients with renal carcinoma the authors extended these studies by using a larger number of tumor markers. In 15 patients (11 men and 4 women after menopause) aged 33 to 74 years who had renal carcinoma, among them 3 with tumor metastases, the serum concentration of TPA, CA 12-5, CEA, AFP, ferritin, prolactin, ..beta..-HCG, and ..beta../sub 2/-microglobulin was measured by radioimmunoassay. Monoclonal antibodies were used in the determination of serum CA 12-5 and CEA. In all patients surgical treatment, irradiation, or cytostatic therapy had not been performed. In serum the normal range was exceeded by TPA in 7 patients, CA 12-5 in 3, CEA and AFP in one each, ferritin in 12, prolactin in 2, and ..beta../sub 2/-microglobulin in 10 patients. In one man serum prolactin was reduced. Serum ..beta..-HCG was normal in all patients. According to these results serum ferritin, TPA, and ..beta../sub 2/-microglobulin are of great value as tumor markers in patients with renal carcinoma. In several patients the increase of serum ..beta../sub 2/-microglobulin may be ascribed partly to deterioration of renal function. As no consistent patterns of tumor markers in serum were observed it is recommendedmore » to determine several tumor markers and not only one of them during the follow-up of patients. Radioimmunoassays for measuring the serum level of tumor markers, especially ferritin, TPA, and ..beta../sub 2/-microglobulin, may considerably assist in the management of patients with renal carcinoma by providing early information about tumor recurrence or metastases.« less

Authors:
; ; ;
Publication Date:
Research Org.:
Dept. of Nuclear Medicine, Academic Teaching Hospital, and Dept. of Urology, St.-Josefs-Hospital Krefeld-Uerdingen, Krefeld
OSTI Identifier:
6932894
Report Number(s):
CONF-840619-
Journal ID: CODEN: JNMEA; TRN: 87-008851
Resource Type:
Conference
Journal Name:
J. Nucl. Med.; (United States)
Additional Journal Information:
Journal Volume: 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOLOGICAL MARKERS; RADIOIMMUNOASSAY; CARCINOMAS; DIAGNOSIS; KIDNEYS; AGE DEPENDENCE; FEMALES; FERRITIN; GLOBULINS; IMMUNE SERUMS; LTH; MALES; METASTASES; MONOCLONAL ANTIBODIES; PATIENTS; ANTIBODIES; BODY; COMPLEXES; DISEASES; GONADOTROPINS; HORMONES; IMMUNOASSAY; IMMUNOLOGY; IRON COMPLEXES; ISOTOPE APPLICATIONS; METALLOPROTEINS; NEOPLASMS; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; PITUITARY HORMONES; PROTEINS; RADIOASSAY; RADIOIMMUNOLOGY; TRACER TECHNIQUES; TRANSITION ELEMENT COMPLEXES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Cordoni-Voutsas, M, Glaubitt, D, Wagner, W, and Lichtenberg, T. Radioimmunoassay of tumor markers in serum of patients with renal carcinoma. United States: N. p., 1984. Web.
Cordoni-Voutsas, M, Glaubitt, D, Wagner, W, & Lichtenberg, T. Radioimmunoassay of tumor markers in serum of patients with renal carcinoma. United States.
Cordoni-Voutsas, M, Glaubitt, D, Wagner, W, and Lichtenberg, T. 1984. "Radioimmunoassay of tumor markers in serum of patients with renal carcinoma". United States.
@article{osti_6932894,
title = {Radioimmunoassay of tumor markers in serum of patients with renal carcinoma},
author = {Cordoni-Voutsas, M and Glaubitt, D and Wagner, W and Lichtenberg, T},
abstractNote = {Having noted an increased serum level of TPA and CEA in patients with renal carcinoma the authors extended these studies by using a larger number of tumor markers. In 15 patients (11 men and 4 women after menopause) aged 33 to 74 years who had renal carcinoma, among them 3 with tumor metastases, the serum concentration of TPA, CA 12-5, CEA, AFP, ferritin, prolactin, ..beta..-HCG, and ..beta../sub 2/-microglobulin was measured by radioimmunoassay. Monoclonal antibodies were used in the determination of serum CA 12-5 and CEA. In all patients surgical treatment, irradiation, or cytostatic therapy had not been performed. In serum the normal range was exceeded by TPA in 7 patients, CA 12-5 in 3, CEA and AFP in one each, ferritin in 12, prolactin in 2, and ..beta../sub 2/-microglobulin in 10 patients. In one man serum prolactin was reduced. Serum ..beta..-HCG was normal in all patients. According to these results serum ferritin, TPA, and ..beta../sub 2/-microglobulin are of great value as tumor markers in patients with renal carcinoma. In several patients the increase of serum ..beta../sub 2/-microglobulin may be ascribed partly to deterioration of renal function. As no consistent patterns of tumor markers in serum were observed it is recommended to determine several tumor markers and not only one of them during the follow-up of patients. Radioimmunoassays for measuring the serum level of tumor markers, especially ferritin, TPA, and ..beta../sub 2/-microglobulin, may considerably assist in the management of patients with renal carcinoma by providing early information about tumor recurrence or metastases.},
doi = {},
url = {https://www.osti.gov/biblio/6932894}, journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 25:5,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 1984},
month = {Sun Jan 01 00:00:00 EST 1984}
}

Conference:
Other availability
Please see Document Availability for additional information on obtaining the full-text document. Library patrons may search WorldCat to identify libraries that hold this conference proceeding.

Save / Share: