Prophylaxis of radiation dermatitis with a topical cortisone cream
Nineteen cancer patients receiving radiation therapy to the head, neck, chest wall, or abdomen were evaluated in a double-blind study to determine the effectiveness of 0.2% hydrocortisone valerate vs placebo in reducing acute radiation dermatitis. Patients applied hydrocortisone valerate to one-half of the irradiated area and the placebo to the other half beginning two weeks after the initiation of radiotherapy and continuing until three weeks after completion. Left and right sides were scored each week with respect to erythema, dry desquamation, moist desquamation, ulceraton, and the duration and intensity of symptoms such as soreness, burning, and itching. No statistically significant difference was found between the 0.2% hydrocortisone valerate and the placebo in the acute skin response or the symptoms of radiation dermatitis. The patients were evaluated three months following radiotherapy for evidence of skin atrophy. There was no difference found between hydrocortisone valerate and the placebo with respect to the late effects of radiation therapy.
- Research Organization:
- Pennsylvania State Univ., Hershey
- OSTI ID:
- 6930649
- Journal Information:
- Radiology; (United States), Vol. 143:3
- Country of Publication:
- United States
- Language:
- English
Similar Records
Mometasone Furoate Effect on Acute Skin Toxicity in Breast Cancer Patients Receiving Radiotherapy: A Phase III Double-Blind, Randomized Trial From the North Central Cancer Treatment Group N06C4
Comparison of Provider-Assessed and Patient-Reported Outcome Measures of Acute Skin Toxicity During a Phase III Trial of Mometasone Cream Versus Placebo During Breast Radiotherapy: The North Central Cancer Treatment Group (N06C4)
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
HYDROCORTISONE
EVALUATION
RADIODERMATITIS
RADIOINDUCTION
RADIOTHERAPY
SIDE EFFECTS
SKIN
BIOLOGICAL RADIATION EFFECTS
PATIENTS
ADRENAL HORMONES
BIOLOGICAL EFFECTS
BODY
CORTICOSTEROIDS
DERMATITIS
DISEASES
GLUCOCORTICOIDS
HORMONES
HYDROXY COMPOUNDS
INJURIES
KETONES
LOCAL RADIATION EFFECTS
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PREGNANES
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
SKIN DISEASES
STEROID HORMONES
STEROIDS
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man