Progress report, July 1981-July 1982
Research progress is reported for the period July 1981 through July 1982. Two reactive metabolites of benzo(a)pyrene were compared to determine whether in diploid human fibroblasts, one is more mutagenic than the other and their action compared in diploid Chinese hamster fibroblasts. The mutagenic action of a model compound for aflatoxin was determined in repair-proficient and repair-deficient human cells as an example of a compound similar to benzo(a)pyrene in structure but different in binding to DNA and in mechanism of mutagenesis. It was determined whether diploid human endothelial or epithelial cells can be induced to transform into anchorage independent cells using chemical carcinogens and/or radiation and whether these cell types share steps to tumorigenicity in common with diploid human fibroblasts. (ACR)
- Research Organization:
- Michigan State Univ., East Lansing (USA)
- DOE Contract Number:
- AC02-78EV04659
- OSTI ID:
- 6928515
- Report Number(s):
- DOE/EV/04659-T1; ON: DE82021527
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BENZOPYRENE
METABOLITES
ENDOTHELIUM
ONCOGENIC TRANSFORMATIONS
EPITHELIUM
FIBROBLASTS
MUTAGENESIS
AFLATOXIN
CELL CULTURES
HAMSTERS
MAN
RADIOINDUCTION
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AROMATICS
BODY
CONDENSED AROMATICS
CONNECTIVE TISSUE CELLS
HYDROCARBONS
MAMMALS
ORGANIC COMPOUNDS
PRIMATES
RODENTS
SOMATIC CELLS
TISSUES
VERTEBRATES
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)
560121 - Radiation Effects on Cells- External Source- (-1987)