Effect of hypertransfusion on bone marrow regeneration in sublethally irradiated mice. I. Enhanced granulopoietic recovery
Hypertransfusion can enhance recovery from neutropenia in certain clinical and experimental situations. We have studied the pattern of myeloid recovery in mice hypertransfused after receiving 350 rads whole body irradiation. Both hypertransfused and control groups showed the degenerative phase, abortive rise, and regenerative phase that has been described following sublethal irradiation. The blood granulocyte counts in the hypertransfused group returned to normal more rapidly and were maintained at a significantly higher level during the regenerative phase. This difference is not the result of a shift in granulocytes from the marrow granulocyte reserve or marginal granulocyte pool to the circulating pool, but is associated with significantly enhanced bone marrow granulopoiesis. While the total bone marrow cellularity of the hypertransfused mice is less than that of the control mice, the hypertransfused group contains more CFU-GM and myeloid cells during the regenerative phase. The enhanced granulopoiesis is not due to increased colony-stimulating activity (CSA) levels in the hypertransfused mice, as the CSA levels were significantly lower in this group compared to the controls prior to and during the initial phase of granulopoietic recovery. This study suggests that hypertransfusion increases the rate of recovery of myelopoiesis by increasing the number of precursors available for myeloid differentiation from an earlier stem cell compartment.
- Research Organization:
- St. Jude Children's Research Hospital, Memphis, TN
- OSTI ID:
- 6925934
- Journal Information:
- Blood; (United States), Vol. 56:1
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
BONE MARROW
BIOLOGICAL REGENERATION
RADIATION EFFECTS
TRANSFUSIONS
BIOLOGICAL EFFECTS
CFU
IRRADIATION
LEUKOCYTES
MICE
MYELOID LEUKEMIA
PATHOLOGICAL CHANGES
RADIATION DOSES
ANIMAL TISSUES
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
DISEASES
DOSES
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
LEUKEMIA
MAMMALS
MATERIALS
NEOPLASMS
ORGANS
RECOVERY
RODENTS
THERAPY
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
550900 - Pathology