Detection of CCl/sub 4/-induced oxidation of hepatic tissue in vivo by oxygen-18 tracing
Abstract
Oxygen can become a damaging influence in tissues and cells exposed to environmental pollutants. This paper describes the first application of a new technique for tracing oxygen in tissues exposed to pollutants. Carbon tetrachloride (CCl/sub 4/) was found to cause oxidation of liver tissue in rats which was measurable using oxygen-18 labeling procedures. Rats that breathed oxygen-18 while being exposed to CCl/sub 4/ were found to have oxidized lipids, macromolecules, and water-soluble substances in their livers. The techniques outlined in the paper should be useful for elucidating mechanisms of injury and increased aging of tissues exposed to pollutants.
- Authors:
- Publication Date:
- Research Org.:
- Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
- OSTI Identifier:
- 6924615
- Report Number(s):
- PB-88-224381/XAB; EPA-600/J-88/041
- Resource Type:
- Technical Report
- Resource Relation:
- Other Information: Pub. in Toxicology and Applied Pharmacology, Vol. 93, 81-88(1988)
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; LIVER CELLS; OXIDATION; OXYGEN 18; TRACER TECHNIQUES; POLLUTANTS; BIOLOGICAL EFFECTS; CARBON TETRACHLORIDE; IN VIVO; LABORATORY ANIMALS; LIPIDS; MOLECULES; ANIMAL CELLS; CHEMICAL REACTIONS; CHLORINATED ALIPHATIC HYDROCARBONS; EVEN-EVEN NUCLEI; HALOGENATED ALIPHATIC HYDROCARBONS; ISOTOPE APPLICATIONS; ISOTOPES; LIGHT NUCLEI; NUCLEI; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; OXYGEN ISOTOPES; SOMATIC CELLS; STABLE ISOTOPES; 550300* - Cytology
Citation Formats
Hatch, G E, Santrock, J, Slade, R, and Hayes, J M. Detection of CCl/sub 4/-induced oxidation of hepatic tissue in vivo by oxygen-18 tracing. United States: N. p., 1988.
Web.
Hatch, G E, Santrock, J, Slade, R, & Hayes, J M. Detection of CCl/sub 4/-induced oxidation of hepatic tissue in vivo by oxygen-18 tracing. United States.
Hatch, G E, Santrock, J, Slade, R, and Hayes, J M. 1988.
"Detection of CCl/sub 4/-induced oxidation of hepatic tissue in vivo by oxygen-18 tracing". United States.
@article{osti_6924615,
title = {Detection of CCl/sub 4/-induced oxidation of hepatic tissue in vivo by oxygen-18 tracing},
author = {Hatch, G E and Santrock, J and Slade, R and Hayes, J M},
abstractNote = {Oxygen can become a damaging influence in tissues and cells exposed to environmental pollutants. This paper describes the first application of a new technique for tracing oxygen in tissues exposed to pollutants. Carbon tetrachloride (CCl/sub 4/) was found to cause oxidation of liver tissue in rats which was measurable using oxygen-18 labeling procedures. Rats that breathed oxygen-18 while being exposed to CCl/sub 4/ were found to have oxidized lipids, macromolecules, and water-soluble substances in their livers. The techniques outlined in the paper should be useful for elucidating mechanisms of injury and increased aging of tissues exposed to pollutants.},
doi = {},
url = {https://www.osti.gov/biblio/6924615},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1988},
month = {Fri Jan 01 00:00:00 EST 1988}
}
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