In vivo red blood cell compatibility testing using indium-113m tropolone-labeled red blood cells

Journal Article · Sun May 01 00:00:00 EDT 1988 · J. Nucl. Med.; (United States)

OSTI ID:6924175

Morrissey, G J; Gravelle, D; Dietz, G; Driedger, A A; King, M; Cradduck, T D

In vivo radionuclide crossmatch is a method for identifying compatible blood for transfusion when allo- or autoantibodies preclude the use of conventional crossmatching techniques. A technique for labeling small volumes of donor red blood cells with (/sup 113m/In)tropolone is reported. The use of /sup 113m/In minimizes the accumulation of background radioactivity and the radiation dose especially so when multiple crossmatches are performed. Labeling red cells with (/sup 113m/In)tropolone is faster and easier to perform than with other radionuclides. Consistently high labeling efficiencies are obtained and minimal /sup 113m/In activity elutes from the labeled red blood cells. A case study involving 22 crossmatches is presented to demonstrate the technique. The radiation dose equivalent from /sup 113m/In is significantly less than with other radionuclides that may be used to label red cells.

• Research Organization: Victoria Hospital, London, Ontario (Canada)
• OSTI ID: 6924175
• Journal Information: J. Nucl. Med.; (United States), Vol. 29:5
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ERYTHROCYTES
LABELLING
NUCLEAR MEDICINE
TRACER TECHNIQUES
DOSE EQUIVALENTS
IN VIVO
INDIUM 113
ISOMERIC NUCLEI
ORGANOMETALLIC COMPOUNDS
RADIATION DOSES
TRANSFUSIONS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
DOSES
HOURS LIVING RADIOISOTOPES
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MATERIALS
MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
RADIOISOTOPES
STABLE ISOTOPES
THERAPY
550601* - Medicine- Unsealed Radionuclides in Diagnostics