Effects of carbon dioxide on Penicillium chrysogenum: an autoradiographic study

Journal Article · Mon Jun 20 00:00:00 EDT 1988 · Biotechnol. Bioeng.; (United States)

DOI:https://doi.org/10.1002/bit.260320103· OSTI ID:6922279

Edwards, A G; Ho, C S

Previous research has shown that dissolved carbon dioxide causes significant changes in submerged penicillin fermentations, such as stunted, swollen hyphae, increased branching, lower growth rates, and lower penicillin productivity. Influent carbon dioxide levels of 5 and 10% were shown through the use of autoradiography to cause an increase in chitin synthesis in submerged cultures of Penicillium chrysogenum. At an influent 5% carbon dioxide level, chitin synthesis is ca. 100% greater in the subapical region of P. chrysogenum hyphae than that of the control, in which there was no influent carbon dioxide. Influent carbon dioxide of 10% caused an increase of 200% in chitin synthesis. It is believed that the cell wall must be plasticized before branching can occur and that high amounts of dissolved carbon dioxide cause the cell to lose control of the plasticizing effect, thus the severe morphological changes occur.

• Research Organization: State Univ. of New York, Buffalo (USA)
• OSTI ID: 6922279
• Journal Information: Biotechnol. Bioeng.; (United States), Vol. 32:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
CARBON DIOXIDE
TOXICITY
PENICILLIUM
MORPHOLOGICAL CHANGES
AUTORADIOGRAPHY
CELL WALL
GROWTH
PENICILLIN
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
CARBON COMPOUNDS
CARBON OXIDES
CELL CONSTITUENTS
CHALCOGENIDES
DRUGS
FUNGI
OXIDES
OXYGEN COMPOUNDS
PLANTS
560300* - Chemicals Metabolism & Toxicology
550801 - Morphology- Tracer Techniques