Effects of the kappa opioid receptor antagonist MR-2266-BS on the acquisition of ethanol preference

Journal Article · Mon Jan 01 00:00:00 EST 1990 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(90)90448-Z· OSTI ID:6919325

Sandi, C; Borrell, J; Guaza, C ^[1]

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1. Cajal Institute, Madrid (Spain)

Using a paradigm by which rats forced to drink a weak ethanol solution develop ethanol preference in consecutive retention testing days, the effects of the administration of the kappa opioid antagonist MR-2266-BS, prior to or after the forced ethanol session, were studied. Pre-conditioning subcutaneous (s.c.) administration of 1 mg/kg of MR-2266-BS induced a decrease in subsequent ethanol consumption without significantly modifying the acquisition of ethanol preference. Post-conditioning administration of MR-2266-BS induced both a dose-dependent reduction in ethanol consumption and in preference throughout the three following days. The results of the present study provide further support of the involvement of kappa-type opioids on drinking behavior, and suggest that kappa receptors may be involved in the consumption and development of preference to ethanol.

• OSTI ID: 6919325
• Journal Information: Life Sciences; (USA), Vol. 46:15; ISSN 0024-3205
• Country of Publication: United States
• Language: English

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