Renal amyloidosis. Evaluation by gallium imaging

Journal Article · Mon Sep 01 00:00:00 EDT 1986 · Clin. Nucl. Med.; (United States)

DOI:https://doi.org/10.1097/00003072-198609000-00012· OSTI ID:6915988

Lee, V W; Skinner, M; Cohen, A S; Ngai, S; Peng, T T

A study has been performed to evaluate the efficacy of gallium imaging in the detection of renal amyloidosis. Ten of the 11 patients who had biopsy-proven renal amyloidosis demonstrated marked uptake in both kidneys. One patient revealed moderate gallium uptake in his kidneys. None of the patients had underlying renal or extrarenal pathology other than amyloidosis, which could account for renal gallium uptake (renal infection, neoplasm, hepatic failure or frequent blood transfusions). Four patients also had extrarenal foci of abnormal gallium uptake, suggesting other sites of amyloid deposits. Our data strongly suggest that gallium imaging has a high sensitivity for detection of renal amyloidosis. Its specificity is enhanced significantly by careful review of the clinical history to exclude other known causes of renal gallium uptake. Potentially, gallium imaging may be used to monitor the progress of patients under experimental therapy.

• Research Organization: Boston City Hospital, MA
• OSTI ID: 6915988
• Journal Information: Clin. Nucl. Med.; (United States), Vol. 9
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
KIDNEYS
SCINTISCANNING
UROGENITAL SYSTEM DISEASES
DIAGNOSIS
GALLIUM 67
IMAGES
PATHOLOGICAL CHANGES
PATIENTS
UPTAKE
BETA DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics