Body protein status in Fischer 344 rats bearing the MCA sarcoma
The effect of a methylcholanthrene (MCA) sarcoma on the protein status of adult, male, Fischer-344 rats was investigated. Three groups of ten rats were used. One group (TB) was inoculated with MCA sarcoma tissue, control (C) and pair-fed (PF) groups received saline only. Rats were fed a purified (20% casein, 20% fat, 45% sucrose) diet from day 7 post-transplant, when tumors became palpable. Food intake of TB was depressed relative to C at day 15 PT. Animals were killed at day 22 PT. In comparison to C, tumor growth was associated with a decrease in gastrocnemius muscle protein content and an increase in spleen weight and protein content. There was no effect of tumor growth on the weight or protein content of liver, heart, or kidneys. Data from PF animals suggested that decreased gastrocnemius muscle protein content was partly attributable to decreased food intake and partly to tumor growth; the increased spleen protein was due to tumor growth per se. Thus, growth of the MCA sarcoma affects host protein status. Some of these effects are caused partly by hypophagia and partly by tumor growth and others are due to tumor growth per se.
- Research Organization:
- Texas Woman's Univ., Houston
- OSTI ID:
- 6914044
- Report Number(s):
- CONF-8604222-
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:4; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
3-METHYLCHOLANTHRENE
CARCINOGENESIS
PROTEINS
BIOSYNTHESIS
TISSUE DISTRIBUTION
SARCOMAS
GROWTH
HEART
KIDNEYS
LIVER
MUSCLES
RATS
SPLEEN
TOXICITY
ANIMALS
AROMATICS
BODY
CARDIOVASCULAR SYSTEM
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
GLANDS
HYDROCARBONS
MAMMALS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
POLYCYCLIC AROMATIC HYDROCARBONS
RODENTS
SYNTHESIS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550900 - Pathology