Regional distribution of ventilation assessed by Kr-81m scintigraphy employing temporal Fourier transform

Journal Article · Wed Jan 01 00:00:00 EST 1986 · Am. J. Physiol. Imag.; (United States)

OSTI ID:6908606

Slosman, D; Susskind, H; Cinotti, L; van Giessen, J W; Brill, A B

Temporal Fourier analysis was applied to Kr-81m ventilation scintigraphy to determine the amplitude (AMP1) and phase (PHA1) of the first harmonic of a single composite respiratory cycle and to compare regional patterns in subjects with obstructive pulmonary disease (COPD) and nonobstructed subjects. Six nonobstructed subjects, three subjects with small airway disease, six subjects with COPD, and one subject with restrictive disease were investigated. The mean value of the functional PHA1 image (PHA1m) correlated negatively with 1-second forced expiratory volume (FEV1) (r = -0.801, P less than .001), with %FEV1/FVC (r = -0.636, P less than .01) and maximum midexpiratory flow rate (FEF25-75%) (r = -0.723, P less than .002), and correlated positively with residual volume (r = 0.640, P less than .01). PHA1m values for the six subjects with COPD were significantly higher (t = 2.359, P less than .05) than for the ten nonobstructed subjects. Display of phase and amplitude functional images permits a visual evaluation of the regional distribution of ventilation to be made. Regional abnormalities of air flow were detected in obstructed subjects, and the presence of airway obstruction could be predicted. Dynamic ventilation imaging, therefore, appears to be a potentially useful noninvasive technique to assess lung impairment on a localized level.

• Research Organization: Brookhaven National Lab., Upton, NY (USA)
• OSTI ID: 6908606
• Journal Information: Am. J. Physiol. Imag.; (United States), Vol. 1:1
• Country of Publication: United States
• Language: English

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