Role of endogenous opioid peptides in the pathogenesis of motion sickness

Journal Article · Wed Jan 01 00:00:00 EST 1986 · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)

OSTI ID:6906918

Yasnetsov, V V; Il'ina, S L; Karsanova, S K; Medvedev, O S; Mokrousova, A V; Sabaev, V V; Shashkov, V A; Tigranyan, R A; Vakulina, O P

This paper examines the pathogenesis of motion sickness and the role of the various neurochemical systems of the body in the genesis of the condition. It has been shown that the endogenous opioid system participates in the genesis of several pathological processes; this was the motivation for the study. The plasma beta-endorphin level was determined in samples from 19 clinically healthy males. Considering the positive prophylactic and therapeutic effect of naloxone against motion sickness it can be postulated that endogenous opioid peptides participate in the genesis of the vestibulo-autonomic disorders in motion sickness.

• Research Organization: Institute of Medical-Biological problems, Ministry of Health of the USSR
• OSTI ID: 6906918
• Journal Information: Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 100:8
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BLOOD PLASMA
RADIOIMMUNOASSAY
ENDORPHINS
MEN
BIOLOGICAL STRESS
NAUSEA
NARCOTICS
BIOLOGICAL EFFECTS
PEPTIDES
DOSE-RESPONSE RELATIONSHIPS
EQUILIBRIUM
MOTION
PATHOGENESIS
QUANTITY RATIO
RECEPTORS
RETENTION
VESTIBULAR APPARATUS
VOMITING
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
MALES
MAMMALS
MAN
MATERIALS
MEMBRANE PROTEINS
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
PROTEINS
RADIOASSAY
RADIOIMMUNOLOGY
SENSE ORGANS
SYMPTOMS
TRACER TECHNIQUES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques