Incorporation of stable and radioactive isotopes via organoborane chemistry
An organic synthesis involving the use of organoboranes rather than the traditional substitution reactions and Grignard reagents for the rapid preparation of physiologically active materials labelled with short-lived isotopes is discussed in detail. The iodination reaction for incorporating I-123 or I-125 into compounds was found to proceed via an electrophilic attack by the iodine molecule on the electron-rich borax complex, did not require the presence of strong base, and was complete in 60 sec. The procedure also uses radiolabeled NaI rather than the more unstable iodine monochloride usually used. A similar procedure was developed for labelling compounds with Br-77. Other direct one-pot syntheses are described for incorporation of O-17, N-13, N-15, C-11, and C-13 into compounds very rapidly.
- Research Organization:
- Univ. of Tennessee, Knoxville
- OSTI ID:
- 6900935
- Journal Information:
- Acc. Chem. Res.; (United States), Vol. 17:6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
BROMINE 77
RADIOCHEMISTRY
CARBON 11
IODINE 123
IODINE 125
LABELLED COMPOUNDS
CHEMICAL PREPARATION
NITROGEN 13
NITROGEN 15
OXYGEN 17
BORANES
TRACER TECHNIQUES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BORON COMPOUNDS
BROMINE ISOTOPES
CARBON ISOTOPES
CHEMISTRY
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NITROGEN ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
OXYGEN ISOTOPES
RADIOISOTOPES
STABLE ISOTOPES
SYNTHESIS
400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
550601 - Medicine- Unsealed Radionuclides in Diagnostics