Boron neutron capture therapy: A guide to the understanding of the pathogenesis of late radiation damage to the rat spinal cord
- Univ. of Oxford (United Kingdom)
- Brookhaven National Lab., Upton, NY (United States)
Before the commencement of new boron neutron capture therapy (BNCT) clinical trials in Europe and North America, detailed information on normal tissue tolerance is required. In this study, the pathologic effects of BNCT on the central nervous system (CNS) have been investigated using a rat spinal cord model. The neutron capture agent used was [sup 10]B-enriched sodium mercaptoundecahydro-closo-dodecaborate (BSH), at a dosage of 100 mg/kg body weight. Rats were irradiated on the thermal beam at the Brookhaven Medical Research Reactor. The large spine of vertebra T[sub 2] was used as the lower marker of the irradiation field. Rats were irradiated with thermal neutrons alone to a maximum physical absorbed dose of 11.4 Gy, or with thermal neutrons in combination with BSH, to maximum absorbed physical doses of 5.7 Gy to the CNS parenchyma and 33.7 Gy to the blood in the vasculature of the spinal cord. An additional group of rats was irradiated with 250 kVp X-rays to a single dose of 35 Gy. Spinal cord pathology was examined between 5 and 12 months after irradiation. The physical dose of radiation delivered to the CNS parenchyma, using thermal neutron irradiation in the presence of BSH, was a factor of two to three lower than that delivered to the vascular endothelium, and could not account for the level of damage observed in the parenchyma. The histopathological observations of the present study support the hypothesis that the blood vessels, and the endothelial cells in particular, are the critical target population responsible for the lesions seen in the spinal cord after BNCT type irradiation and by inference, after more conventional irradiation modalities such as photons or fast neutrons. 30 refs., 6 figs., 1 tab.
- OSTI ID:
- 6900486
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics; (United States), Vol. 28:5; ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
CENTRAL NERVOUS SYSTEM
BIOLOGICAL RADIATION EFFECTS
NEUTRON CAPTURE THERAPY
SIDE EFFECTS
BIOLOGICAL MODELS
TIME DELAY
BIOLOGICAL EFFECTS
MEDICINE
NERVOUS SYSTEM
NEUTRON THERAPY
NUCLEAR MEDICINE
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
THERAPY
560152* - Radiation Effects on Animals- Animals
550603 - Medicine- External Radiation in Therapy- (1980-)