Tracheal blood flow and luminal clearance of [sup 99m][Tc]-DTPA in sheep

Journal Article · Thu Oct 01 00:00:00 EDT 1992 · Journal of Applied Physiology (1985); (United States)

OSTI ID:6900387

Hanafi, Z; Corfield, D R; Webber, S E; Widdicombe, J G ^[1]

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1. St. George's Hospital Medical School, London (United Kingdom)

Tracheal blood flow and [sup 99m][Tc]-labeled diethylenetriamine pentaacetic acid (DTPA) clearance were measured in the sheep trachea in vivo. The tracheal arteries were isolated and perfused. An isolated segment of tracheal lumen was filled with Krebs-Henseleit solution containing [sup 99m][Tc]-DTPA, and radioactivity was measured in blood from a catheterized tracheal vein. Infusions at constant pressure of methacholine (n=5), albuterol (n=6), and histamine (n=5) increased arterial inflow and venous outflow but decreased [sup 99m][Tc]-DTPA output and concentration. Phenylephrine (n=9) decreased arterial inflow and venous outflow but increased [sup 99m][Tc]-DTPA output and concentration. When the tracheal arteries were initially perfused at constant flow and the flow rate was then changed, 50% increases in flow (n=5) increased perfusion pressure and venous outflow but decreased [sup 99m][Tc]-DTPA output and concentration. Decreases in flow of 50% (n=3) and 100% (n=10) decreased perfusion pressure and venous outflow but increased [sup 99m][Tc]-DTPA output and concentration. Infusion of the same drugs at constant flow produced significant changes in perfusion pressure but no significant changes in venous outflow or, except for histamine, in [sup 99m][Tc]-DTPA output. Thus [sup 99m][Tc]-DTPA output was inversely related to both mechanically and drug-induced changes in tracheal blood flow but, except for histamine, was not directly affected by the drugs. The results may be due to redistribution of blood between collateral circuits and altered interstitial fluid volume affecting [sup 99m][Tc]-DTPA transport across the interstitium. 24 refs., 6 figs., 3 tabs.

• OSTI ID: 6900387
• Journal Information: Journal of Applied Physiology (1985); (United States), Vol. 73:4; ISSN 8750-7587
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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CLEARANCE
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