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Title: Proton nuclear magnetic resonance of regenerating rat liver after partial hepatectomy

Abstract

Spin-lattice (T/sub 1/) and spin-spin (T/sub 2/) proton nuclear magnetic resonance relaxation times were measured over a 48-hours period of experimental liver regeneration in Wistar rats, T/sub 2/ showed an early significant increase reaching a plateau 30% above baseline from the 10th hrs onwards. Laparotomized control animals showed no change in T/sub 2/ values. The increase in T/sub 1/ occurred at a later stage but was no different from that in laparotomized controls. T/sub 1/ reached a peak, 20% above baseline, around the 30th hr. The changes observed were far less marked than those previously described for cancer tissue, which showed about a 60% increase in T/sub 1/ fluctuations followed a circadian pattern, with a minimum at night's end and a maximum around mid-day. No circadian rhythm was seen for T/sub 2/. The observed T/sub 1/ and T/sub 2/ changes are discussed with respect to mitotic and metabolic events known to occur during regeneration of the liver.

Authors:
 [1]; ; ; ;
  1. Univ. of Rennes School of Medicine, France
Publication Date:
OSTI Identifier:
6880015
Resource Type:
Journal Article
Journal Name:
Life Sci.; (United States)
Additional Journal Information:
Journal Volume: 31:6
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; LIVER; BIOLOGICAL REGENERATION; NUCLEAR MAGNETIC RESONANCE; DAILY VARIATIONS; PROTONS; RATS; SPIN-LATTICE RELAXATION; VARIATIONS; ANIMALS; BARYONS; BIOLOGICAL RECOVERY; BODY; DIGESTIVE SYSTEM; ELEMENTARY PARTICLES; FERMIONS; GLANDS; HADRONS; MAGNETIC RESONANCE; MAMMALS; NUCLEONS; ORGANS; RECOVERY; RELAXATION; RESONANCE; RODENTS; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550602 - Medicine- External Radiation in Diagnostics- (1980-)

Citation Formats

de Certaines, J D, Moulinoux, J P, Benoist, L, Benard, A, and Rivet, P. Proton nuclear magnetic resonance of regenerating rat liver after partial hepatectomy. United States: N. p., 1982. Web. doi:10.1016/0024-3205(82)90477-5.
de Certaines, J D, Moulinoux, J P, Benoist, L, Benard, A, & Rivet, P. Proton nuclear magnetic resonance of regenerating rat liver after partial hepatectomy. United States. https://doi.org/10.1016/0024-3205(82)90477-5
de Certaines, J D, Moulinoux, J P, Benoist, L, Benard, A, and Rivet, P. 1982. "Proton nuclear magnetic resonance of regenerating rat liver after partial hepatectomy". United States. https://doi.org/10.1016/0024-3205(82)90477-5.
@article{osti_6880015,
title = {Proton nuclear magnetic resonance of regenerating rat liver after partial hepatectomy},
author = {de Certaines, J D and Moulinoux, J P and Benoist, L and Benard, A and Rivet, P},
abstractNote = {Spin-lattice (T/sub 1/) and spin-spin (T/sub 2/) proton nuclear magnetic resonance relaxation times were measured over a 48-hours period of experimental liver regeneration in Wistar rats, T/sub 2/ showed an early significant increase reaching a plateau 30% above baseline from the 10th hrs onwards. Laparotomized control animals showed no change in T/sub 2/ values. The increase in T/sub 1/ occurred at a later stage but was no different from that in laparotomized controls. T/sub 1/ reached a peak, 20% above baseline, around the 30th hr. The changes observed were far less marked than those previously described for cancer tissue, which showed about a 60% increase in T/sub 1/ fluctuations followed a circadian pattern, with a minimum at night's end and a maximum around mid-day. No circadian rhythm was seen for T/sub 2/. The observed T/sub 1/ and T/sub 2/ changes are discussed with respect to mitotic and metabolic events known to occur during regeneration of the liver.},
doi = {10.1016/0024-3205(82)90477-5},
url = {https://www.osti.gov/biblio/6880015}, journal = {Life Sci.; (United States)},
number = ,
volume = 31:6,
place = {United States},
year = {Mon Aug 09 00:00:00 EDT 1982},
month = {Mon Aug 09 00:00:00 EDT 1982}
}