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Title: Metronidazole as a radiosensitizer: a preliminary report on estimation in serum and saliva

Some studies indicate the clinical benefit of hypoxic radiosensitizers in patients who are undergoing radiotherapy. Serum level of sensitizers are usualy advised; however they are very demanding on the patient. Saliva level of the sensitizers may be an alternative method. This study correlated serum level of metronidazole to the saliva level in 10 patients who were undergoing radiotherapy with the sensitizer. A change to the saliva level method appears to relieve the patients.
Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
6879682
Resource Type:
Conference
Resource Relation:
Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States); Journal Volume: 6:9
Research Org:
Free Univ., Amsterdam, Netherlands
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD SERUM; COMPARATIVE EVALUATIONS; METRONIDAZOLE; SAMPLING; SALIVA; TIME DEPENDENCE; ANOXIA; LIQUID COLUMN CHROMATOGRAPHY; PATIENTS; RADIOTHERAPY; ALCOHOLS; AZOLES; BIOLOGICAL MATERIALS; BODY FLUIDS; CHROMATOGRAPHY; DRUGS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IMIDAZOLES; MATERIALS; MEDICINE; NITRO COMPOUNDS; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIOLOGY; RADIOSENSITIZERS; RESPONSE MODIFYING FACTORS; SEPARATION PROCESSES; THERAPY 560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987); 550603 -- Medicine-- External Radiation in Therapy-- (1980-)