DNA clone of human type IV collagenase
This patent relates to type IV collagenase, herein after also referred to as gelatinase. More particularly, the patent relates to the cDNA clone representing the full size human type IV collagenase (gelatinase). Collagens constitute the most abundant proteins of the extracellular matrix (ECM) in mammalian organisms. Collagen and other macromolecules of the ECM are deposited by resident cells and organized into a three-dimensional meshwork. This ECM environment plays an essential role in guiding cell migration, and in cell-to-cell communication during morphogenetic processes. The restructuring of the ECM during remodeling occurs as a cooperative multistep process involving a localized degradation of existing macromolecules, rearrangement of the cytoskeleton, cell translocation, and deposition of new ECM components.
- Assignee:
- Washington Univ., St. Louis, MO (USA)
- Patent Number(s):
- US 4923818; A
- Application Number:
- PPN: US 7-352069A
- OSTI ID:
- 6875627
- Resource Relation:
- Patent File Date: 15 May 1989
- Country of Publication:
- United States
- Language:
- English
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