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Title: Derivatized gold clusters and antibody-gold cluster conjugates

Antibody- or antibody fragment-gold cluster conjugates are shown wherein the conjugate size can be as small as 5.0 nm. Methods and reagents are disclosed in which antibodies, Fab' or F(ab')[sub 2] fragments are covalently bound to a stable cluster of gold atoms. The gold clusters may contain 6, 8, 9, 11, 13, 55 or 67 gold atoms in their inner core. The clusters may also contain radioactive gold. The antibody-cluster conjugates are useful in electron microscopy applications as well as in clinical applications that include imaging, diagnosis and therapy. 7 figs.
Authors:
;
Publication Date:
OSTI Identifier:
6871214
Report Number(s):
US 5360895; A
PPN: US 7-988338
DOE Contract Number:
AC02-76CH00016
Resource Type:
Patent
Resource Relation:
Patent File Date: 9 Dec 1992
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; ANTIBODIES; LABELLING; GOLD ISOTOPES; RADIOIMMUNODETECTION; RADIOIMMUNOTHERAPY; RADIOPHARMACEUTICALS; DIAGNOSTIC TECHNIQUES; DRUGS; IMMUNOTHERAPY; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; MEDICINE; NUCLEAR MEDICINE; RADIOLOGY; RADIOTHERAPY; THERAPY; TRACER TECHNIQUES 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics; 550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-); 550201 -- Biochemistry-- Tracer Techniques